Results 141 to 150 of about 1,381,466 (410)

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, EarlyView.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

Attitudes toward Management of Sickle Cell Disease and Its Complications: A National Survey of Academic Family Physicians

Anemia, 2015
Objective. Sickle cell disease (SCD) is a disease that requires a significant degree of medical intervention, and family physicians are one potential provider of care for patients who do not have access to specialists.
Arch G. Mainous, Rebecca J. Tanner, Christopher A. Harle, Richard Baker, Navkiran K. Shokar, Mary M. Hulihan   +5 more
doaj   +1 more source

Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells [PDF]

, 2014
Kenneth K. Karanja, Eu Han Lee, Eric A. Hendrickson, Judith L. Campbell   +3 more
openalex   +1 more source

Brain BOLD and NIRS response to hyperoxic challenge in sickle cell disease and chronic anemias

, 2023
Chau Vu, Adam Bush, Matthew Borzage, Soyoung Choi, Julie Coloigner, Shayan Farzad, Yaqiong Chai, Thomas D. Coates, John C. Wood   +8 more
openalex   +2 more sources

IST Combined with Full-Dose Rhtpo in the Treatment of Severe Aplastic Anemia -a Prospective Single-Center Clinical Study [PDF]

, 2023
Huihui Fan, Jing Hu, Wenrui Yang, Xin Zhao, Li Zhang, Kang Zhou, Youzhen Xiong, Liping Jing, Fengkui Zhang   +8 more
openalex   +1 more source

Novel mutation in addition to functional TMPRSS6 gene polymorphisms originate an IRIDA-like phenotype in an African child [PDF]

, 2019
Iron-refractory iron deficiency anemia (IRIDA) is a rare autosomal recessive anemia often unresponsive to oral iron intake and partially responsive to parenteral iron treatment. The disease originates from mutations in TMPRSS6 gene, encoding Matriptase 2,
Batalha, Sara, Faleiro, Bárbara D., Faustino, Paula, Lavinha, João, Machado, Miguel P., Maia, Raquel, Mendonça, Joana, Vieira, Luís   +7 more
core  

Active Force Dynamics in Red Blood Cells Under Non‐Invasive Optical Tweezers

Advanced Science, EarlyView.
A non‐invasive method combines low‐power optical tweezers with high‐speed microscopy to simultaneously monitor local membrane forces and displacements in single human red blood cells. This dual‐channel approach reveals a mechano‐dynamic signature that correlates the cell's metabolic state with its mechanical activity. This energetic framework serves as
Arnau Dorn, Clara Luque‐Rioja, Macarena Calero, Diego Herráez‐Aguilar, Francisco Monroy, Niccolò Caselli   +5 more
wiley   +1 more source

The Properties of Red Blood Cells from Patients Heterozygous for HbS and HbC (HbSC Genotype)

Anemia, 2011
Sickle cell disease (SCD) is one of the commonest severe inherited disorders, but specific treatments are lacking and the pathophysiology remains unclear.
A. Hannemann, E. Weiss, D. C. Rees, S. Dalibalta, J. C. Ellory, J. S. Gibson   +5 more
doaj   +1 more source

Ex Vivo Treatment By Mitapivat, an Allosteric Pyruvate Kinase Activator, Reduced Oxidative Stress and Promoted Terminal Erythropoiesis in a Severe Hemolytic Anemia Patient Due to Krϋppel-like Factor 1 Mutations [PDF]

, 2023
Thidarat Suksangpleng, Kalaya Tachavanich, Vip Viprakasit   +2 more
openalex   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source