Results 261 to 270 of about 946,861 (341)

Population Pharmacokinetics and Exposure‐Response Analysis of First‐Line Osimertinib Plus Chemotherapy in Patients with EGFR‐Mutated Advanced NSCLC

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Osimertinib, a third‐generation, central nervous system‐active epidermal growth factor receptor‐tyrosine kinase inhibitor, potently and selectively inhibits epidermal growth factor receptor‐tyrosine kinase inhibitor sensitizing and T790M resistance mutations, with efficacy in epidermal growth factor receptor‐mutated non‐small cell lung cancer.
Jincheng Yang   +10 more
wiley   +1 more source

Beyond Simple Grinding: Methylammonium Chloride Promotes Sustainable, Cylinder‐Free Mechanochemical Synthesis of Deferiprone

open access: yesChemSusChem, EarlyView.
Deferiprone is synthesized under solvent‐free mechanochemical conditions using ball milling. Methylammonium chloride and KOH enable efficient substitution of the oxygen atom in the maltol scaffold with a methylamine moiety, avoiding the limitations of methylamine solutions.
Francesco Basoccu   +6 more
wiley   +1 more source

Sickle Cell Disease: Genetics, Cellular and Molecular Mechanisms, and Therapies

open access: yesAnemia, 2012
Betty S. Pace   +2 more
doaj   +1 more source

Frequency and stability of populations of CD4+ and CD4+CD25+Foxp3+CD127lo Treg in healthy adults defined by cytometry using monoclonal antibodies to T cell associated molecules

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Monitoring subpopulations of CD4+ T cells in blood, especially regulatory CD4+CD25+Foxp3+CD127loT cells, has the potential to identify tolerance to transplants and defects that cause autoimmunity. CD45RA is expressed by naïve/resting CD4+, not by activated cells.
Nirupama D. Verma   +7 more
wiley   +1 more source

Late Pleistocene to Holocene sedimentation in the Great Blue Hole (Lighthouse Reef, Belize): Results from a 30 m long core

open access: yesThe Depositional Record, EarlyView.
A 30 m long sedimentary succession at the bottom of the Belize Blue Hole represents terrestrial cenote (12.5–7.2 ka BP), restricted marine swamp (7.2–5.7 ka BP) and fully marine lagoonal phases (5.7–0 ka BP) on Lighthouse Reef carbonate platform. Post‐glacial and Holocene sea‐level rise largely controlled the sedimentological, faunal and floral changes
Eberhard Gischler   +12 more
wiley   +1 more source

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