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[Anemoside B4 regulates fatty acid metabolism reprogramming in mice with colitis-associated cancer].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023The study aimed to investigate the effect of anemoside B4(B4) on fatty acid metabolism in mice with colitis-associated cancer(CAC). The CAC model was established by azoxymethane(AOM)/dextran sodium sulfate(DSS) in mice. Mice were randomly divided into a normal group, a model group, and low-, medium-, and high-dose anemoside B4 groups.
Xin, Yang +7 more
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Anemoside B4 improves cardiac function after myocardial infarction by regulating HTR2A/ERK pathway
International ImmunopharmacologyAssessing the role of anemoside B4 (B4) in myocardial infarction (MI) and the regulatory mechanism was the purpose of this study.We established MI rat model through ligation of the left anterior descending coronary artery and cardiomyocyte injury model through H2O2 stimulation.
Mei, Lv, Qing, Sun, Yilin, Yu, Dawei, Yu
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Biomedical Chromatography, 2017
AbstractPulsatilla chinensis saponins, the major active components in the herb, have drawn great attention as potential hepatitis B virus infection and hepatoma treatments. Here, a sensitive and accurate HPLC–MS/MS method was established for simultaneous determination of three saponins – anemoside B4, anemoside A3 and 23‐hydroxybetulinic acid – in rat ...
Xiaozhen Guo +10 more
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AbstractPulsatilla chinensis saponins, the major active components in the herb, have drawn great attention as potential hepatitis B virus infection and hepatoma treatments. Here, a sensitive and accurate HPLC–MS/MS method was established for simultaneous determination of three saponins – anemoside B4, anemoside A3 and 23‐hydroxybetulinic acid – in rat ...
Xiaozhen Guo +10 more
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Phytomedicine
Anemoside B4 (AB4), a pentacyclic triterpenoid saponin, exhibits potent anti-inflammatory and antioxidant activities; however, it has poor oral bioavailability. Hypobaric hypoxia (HH) can induce high-altitude acute lung injury (ALI) through inflammatory response and oxidative stress pathways, highlighting the need for effective targeted therapies.This ...
Yuewen Wen +8 more
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Anemoside B4 (AB4), a pentacyclic triterpenoid saponin, exhibits potent anti-inflammatory and antioxidant activities; however, it has poor oral bioavailability. Hypobaric hypoxia (HH) can induce high-altitude acute lung injury (ALI) through inflammatory response and oxidative stress pathways, highlighting the need for effective targeted therapies.This ...
Yuewen Wen +8 more
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Advanced Therapeutics
AbstractIn diabetic kidney disease (DKD), inflammation exacerbated by oxidative stress (ROS) is pivotal. This study investigates the impact of Anemoside B4 (B4), an anti‐inflammatory drug, on kidney cell populations in DKD mice using single‐cell RNA sequencing (scRNA‐seq) and mass spectrometry‐based proteomics, focusing on its hypoglycemic, anti ...
Chunting Zhang +12 more
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AbstractIn diabetic kidney disease (DKD), inflammation exacerbated by oxidative stress (ROS) is pivotal. This study investigates the impact of Anemoside B4 (B4), an anti‐inflammatory drug, on kidney cell populations in DKD mice using single‐cell RNA sequencing (scRNA‐seq) and mass spectrometry‐based proteomics, focusing on its hypoglycemic, anti ...
Chunting Zhang +12 more
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Therapeutic potential of triterpenoid saponin anemoside B4 from
Pharmacological Research, 2020Yan-Hong Li, Richard Weinshilboum
exaly
APPLICATION OF ANEMOSIDE B4 IN PREPARATION OF DRUG FOR TREATMENT OR PREVENTION OF PSORIASIS
2023GAO HONGWEI +3 more
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