Results 181 to 190 of about 31,241 (219)

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Light Chain Cardiac Amyloidosis With Skeletal Muscle Weakness. [PDF]

JACC Case Rep
Montgomery E, Gorrie N, McCaughan G, Nadel J, Shahi K, Bart NK, Carroll AS.   +6 more
europepmc   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Ultrasound-Guided Revision Carpal Tunnel Release for Incomplete Open Carpal Tunnel Release: Using Magnetic Resonance Imaging to Guide Sonographic Access. [PDF]

J Hand Surg Glob Online
Jobe CM.
europepmc   +1 more source

Analysis of the safety and efficacy of single-stage spinal cord stimulation implantation under general anesthesia for high-risk diabetic feet. [PDF]

IBRO Neurosci Rep
Chen X, Zhu B, Li Z.
europepmc   +1 more source

Hybrid periventricular surgery for ventricular septal defects in children: a single-center large-cohort study in Kazakhstan. [PDF]

Front Cardiovasc Med
Marassulov S, Baigenzhin A, Adilbekova A, Akhmoldayeva A, Murzabayeva S, Raimkhanov T, Maiorov R, Aldabergenov Y, Kabaev U, Tolegenuly A, Bebezov I, Tlepov N, Lookin O, Teng X, Pan X.   +14 more
europepmc   +1 more source

Persistence of atrioventricular nodal re-entrant tachycardia during ventricular fibrillation. [PDF]

HeartRhythm Case Rep
Simon L, Rosseel T, Robyns T, Vandenberk B.   +3 more
europepmc   +1 more source