Results 41 to 50 of about 162,170 (267)
The thermodynamics of general anesthesia [PDF]
Biophys. J. 92 (2007) 3159-3165, 2006 It is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found close to body temperature in biomembranes. We propose a thermodynamic extension of the Meyer-Overton
arxiv +1 more source
Radical pairs may play a role in xenon-induced general anesthesia [PDF]
Sci Rep 11, 6287 (2021), 2020 Understanding the mechanisms underlying general anesthesia would be a key step towards understanding consciousness. The process of xenon-induced general anesthesia has been shown to involve electron transfer, and the potency of xenon as a general anesthetic exhibits isotopic dependence. We propose that these observations can be explained by a mechanism
arxiv +1 more source
Медицина болю, 2020 To date, much research has focused on finding the ideal adjuvant for local anesthetics. Each of them can have different effects. In anesthesiology and pain medicine, depending on the purpose, one or another effect may be desirable.
Dmytro Dmytriiev +2 more
doaj +1 more source
Population pharmacokinetics of levobupivacaine during a transversus abdominis plane block in children [PDF]
Therapeutic Drug Monitoring, Lippincott, Williams & Wilkins, 2019,
pp.1, 2019 BACKGROUND:Levobupivacaine is commonly used during transversus abdominis plane block in pediatric patients. However, the dosing regimen is still empirical, and the pharmacokinetic properties of levobupivacaine are not considered. Here, the pharmacokinetics of levobupivacaine during an ultrasound-guided transversus abdominis plane block were evaluated ...
arxiv +1 more source
Кубанский научный медицинский вестник, 2018 Aim. To evaluate anesthesia according to the central hemodynamic, oxygen, acid-base, temperature homeostasis, neuromuscular conduction monitoring the depth of anesthesia and recovery postanesthesia consciousness.Materials and methods.
R. V. VEYLER
doaj +1 more source
Increasing Robustness of the Anesthesia Process from Difference Patient's Delay Using a State-Space Model Predictive Controller [PDF]
Procedia Engineering 15 (2011) 928-932, 2013 The process of anesthesia is nonlinear with time delay and also there are some constraints which have to be considered in calculating administrative drug dosage. We present an Extended Kalman Filter (EKF) observer to estimate drug concentration in the patient's body and use this estimation in a state-space based Model of Predictive Controller (MPC) for
arxiv +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies
Molecular Oncology, EarlyView.Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren +16 more
wiley +1 more source
Вестник анестезиологии и реаниматологии, 2017 A randomized trial was conducted in 22 patients with a body mass index of 44.9 ± 1.6 kg/m2 and morbid obesity who underwent endoscopic sleeve gastroplasty.
M. I. Neimark +2 more
doaj +1 more source
Membrane Nanodomains Homeostasis During Propofol Anesthesia as Function of Dosage and Temperature [PDF]
, 2020 Some anesthetics bind and potentiate gamma-aminobutyric-acid-type receptors, but no universal mechanism for general anesthesia is known. Furthermore, often encountered complications such as anesthesia induced amnesia are not understood. General anesthetics are hydrophobic molecules easily dissolving into lipid bilayers.
arxiv +1 more source