Results 41 to 50 of about 48,692 (290)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Adjuvants in pain medicine. Selection of the drug depending on the desired effect – so which drug to choose?

Медицина болю, 2020
To date, much research has focused on finding the ideal adjuvant for local anesthetics. Each of them can have different effects. In anesthesiology and pain medicine, depending on the purpose, one or another effect may be desirable.
Dmytro Dmytriiev, Yevhenii Lisak, Olesia Zaletska   +2 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

COMBINED ANESTHESIA BY SEVOFLURANE AND FENTANYL IN ELDERLY PATIENTS WITH DIFFERENT REACTIVITY OF THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS

Кубанский научный медицинский вестник, 2018
Aim. To evaluate anesthesia according to the central hemodynamic, oxygen, acid-base, temperature homeostasis, neuromuscular conduction monitoring the depth of anesthesia and recovery postanesthesia consciousness.Materials and methods.
R. V. VEYLER
doaj   +1 more source

Activity-dependent plasticity of transmitter release from nerve terminals in rat fast and slow muscles [PDF]

, 2018
Available under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.Peer reviewedPublisher ...
Bewick, Guy Smith, Lomo, T., Martinov, V. N., Nja, A., Reid, Brian   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

MODERN ANESTHESIA STRATEGIES FOR PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY IN PATIENTS WITH CHRONIC LOWER LIMB ISCHEMIA

Клінічна та профілактична медицина
Introduction. Chronic lower limb ischemia represents a severe manifestation of peripheral arterial disease, associated with elevated risks of complications, disability, and mortality. Percutaneous transluminal angioplasty is a modern treatment option for
Vitalii S. Myrona, Volodymyr I. Cherniy, Oleh I. Nabolotnyi   +2 more
doaj   +1 more source

Maxillary nerve block: A comparison between the greater palatine canal and high tuberosity approaches. [PDF]

, 2018
Aim: Analgesia and anxiolysis during dental procedures are important for dental care and patient compliance. This study aims to compare two classical maxillary nerve block (MNB) techniques: the greater palatine canal (GPC) and the high tuberosity (HT ...
Bacci, C, Bartorelli, Lmg, Ferrario, S, Grossi, Gb, Menozzi, G, Sivolella, S, Zanette, G.   +6 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

COMPARATIVE ASSESSMENT OF CONCOMITANT INHALATIONAL ANESTHESIA MODES IN THE SURGICAL TREATMENT OF MORBID OBESITY

Вестник анестезиологии и реаниматологии, 2017
A randomized trial was conducted in 22 patients with a body mass index of 44.9 ± 1.6 kg/m2 and morbid obesity who underwent endoscopic sleeve gastroplasty.
M. I. Neimark, R. V. Kiselev, A. A. Pantyushin   +2 more
doaj   +1 more source