Results 41 to 50 of about 29,609 (266)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Кубанский научный медицинский вестник, 2018 Aim. To evaluate anesthesia according to the central hemodynamic, oxygen, acid-base, temperature homeostasis, neuromuscular conduction monitoring the depth of anesthesia and recovery postanesthesia consciousness.Materials and methods.
R. V. VEYLER
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Anesthesia in a patient with peripartum cardiomyopathy
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2020 The normal progress of pregnancy, childbirth or the puerperium may occasionally be affected by the onset of heart failure. The origin is mostly caused by the presence of previous cardiovascular disease, known or unknown, and by iatrogenesis.
Karell Piñón-García +2 more
doaj
Вестник анестезиологии и реаниматологии, 2017 A randomized trial was conducted in 22 patients with a body mass index of 44.9 ± 1.6 kg/m2 and morbid obesity who underwent endoscopic sleeve gastroplasty.
M. I. Neimark +2 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Вестник анестезиологии и реаниматологии, 2019 Prevention of cardiovascular complications, which often result in fatal events in the peri-operative period, is one of the most crucial issues of modern anesthesiology.The objective: to investigate the changes in arrhythmic activity and conduction ...
S. A. Sumin +4 more
doaj +1 more source
Local Anesthesia and Conduction Anesthesia
This study is devoted to the characterization of popular local anesthetics and the determination of the mosteffective drugs for local anesthesia. The authors conducted a review of current scientific publications examining theproperties of local anesthetics, their pharmacokinetic and pharmacodynamic characteristics, as well as methods of application.The
Zulfiya Makhmudovna, Buzrukzoda Javohir
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FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source