Results 41 to 50 of about 31,241 (219)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Adjuvants in pain medicine. Selection of the drug depending on the desired effect – so which drug to choose?

Медицина болю, 2020
To date, much research has focused on finding the ideal adjuvant for local anesthetics. Each of them can have different effects. In anesthesiology and pain medicine, depending on the purpose, one or another effect may be desirable.
Dmytro Dmytriiev, Yevhenii Lisak, Olesia Zaletska   +2 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

COMBINED ANESTHESIA BY SEVOFLURANE AND FENTANYL IN ELDERLY PATIENTS WITH DIFFERENT REACTIVITY OF THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS

Кубанский научный медицинский вестник, 2018
Aim. To evaluate anesthesia according to the central hemodynamic, oxygen, acid-base, temperature homeostasis, neuromuscular conduction monitoring the depth of anesthesia and recovery postanesthesia consciousness.Materials and methods.
R. V. VEYLER
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Anesthesia in a patient with peripartum cardiomyopathy

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2020
The normal progress of pregnancy, childbirth or the puerperium may occasionally be affected by the onset of heart failure. The origin is mostly caused by the presence of previous cardiovascular disease, known or unknown, and by iatrogenesis.
Karell Piñón-García, José Antonio Pozo-Romero, Mayda Correa-Borrell   +2 more
doaj  

COMPARATIVE ASSESSMENT OF CONCOMITANT INHALATIONAL ANESTHESIA MODES IN THE SURGICAL TREATMENT OF MORBID OBESITY

Вестник анестезиологии и реаниматологии, 2017
A randomized trial was conducted in 22 patients with a body mass index of 44.9 ± 1.6 kg/m2 and morbid obesity who underwent endoscopic sleeve gastroplasty.
M. I. Neimark, R. V. Kiselev, A. A. Pantyushin   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

ARMYTHMIC ACTIVITY OF MYOCARDIUM AT DIFFERENT STAGES OF ANESTHESIA AND PERI-OPERATIVE PERIOD IN PATIENTS UNDERGOING CHOLECYSTECTOMY

Вестник анестезиологии и реаниматологии, 2019
Prevention of cardiovascular complications, which often result in fatal events in the peri-operative period, is one of the most crucial issues of modern anesthesiology.The objective: to investigate the changes in arrhythmic activity and conduction ...
S. A. Sumin, N. A. Volkova, V. P. Mikhin, E. N. Bogoslovskaya, P. A. Eremin   +4 more
doaj   +1 more source