Results 31 to 40 of about 59,244 (196)

Do dental procedures affect lung function and arterial oxygen saturation in asthmatic patients?

Egyptian Journal of Chest Disease and Tuberculosis, 2013
Background: Asthma is a chronic inflammatory condition of the airways. Pain and anxiety triggered by dental treatment can induce the secretion of endogenous catecholamines.
Magdy Mahmoud Emara, Hussain Abdulallah Yamany, Sally Awad, Tarek A. Elshazly, Ali Shamaa   +4 more
doaj   +1 more source

Propofol attenuates odontogenic/osteogenic differentiation of human dental pulp stem cells in vitro

Journal of Dental Sciences, 2022
Background/purpose: Various studies have used stem cells in the field of bone tissue engineering to repair bone defects. Dental pulp stem cells (DPSCs) have multipotent properties and can be acquired in a noninvasive manner; therefore, they are ...
Eun-Ji Choi, Cheul-Hong Kim, Ji-Young Yoon, Joo-Young Kim, Hyang-Sook Kim, Ji-Uk Yoon, Ah-Reum Cho, Eun-Jung Kim   +7 more
doaj   +1 more source

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

Advanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N. van Ginkel, Wen Sun, Sylvestre Bonnet   +7 more
wiley   +1 more source

Metronidazole‐Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis

Advanced Healthcare Materials, EarlyView.
A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji, Ruichen Zhang, Dongyi Xu, Patrick C. A. van der Wel, Alessia Lasorsa, Guotai Li, Fangze Guo, Qihui Zhou, Patrick van Rijn   +8 more
wiley   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Gentamicin‐Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

Advanced Healthcare Materials, EarlyView.
A bone substitute with gentamicin physically precipitated onto the surface of carbonate apatite exhibits prompt drug release, high bactericidal activity, and osteogenic capacity. Efficient antibacterial activity mitigates early postoperative neutrophil accumulation, the status of which may serve as a potential parameter for evaluating the antibacterial
Linghao Xiao, Gabriela Laranjeira Abe, Jun‐Ichi Sasaki, Haruaki Kitagawa, Ririko Tsuboi, Tomoki Kohno, Satoshi Imazato   +6 more
wiley   +1 more source

Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice

Molecular Autism
Background Fragile X syndrome is caused by the loss of the Fmr1 gene expression. Deletion of Fmr1 in various neuronal and non-neuronal subpopulations in the brain of mice leads to cell-type-specific effects.
Mehdi Hooshmandi, David Ho-Tieng, Kevin C. Lister, Weihua Cai, Calvin Wong, Nicole Brown, Jonathan Fan, Volodya Hovhannisyan, Sonali Uttam, Masha Prager-Khoutorsky, Nahum Sonenberg, Christos G. Gkogkas, Arkady Khoutorsky   +12 more
doaj   +1 more source

Propofol-induced osteogenic differentiation in dental pulp stem cells: Modulation of MAPK signaling under inflammatory conditions

Journal of Dental Sciences
Background/purpose: Bone regeneration in an inflammatory environment remains a significant challenge in the field of regenerative dentistry. Previous studies have demonstrated that inflammation inhibits osteogenic differentiation, necessitating the ...
Mi Kyoung Kim, Giyoung Yun, Cheul-Hong Kim, Ji-Young Yoon, Hee Young Kim, Hyae Jin Kim, Eun-Jung Kim   +6 more
doaj   +1 more source

Postoperative dental morbidity in children following dental treatment under general anesthesia

BMC Oral Health, 2018
Background General anesthesia has been widely used in pediatric dentistry in recent years. However, there remain concerns about potential postoperative dental morbidity.
Yu-Hsuan Hu, Aileen Tsai, Li-Wei Ou-Yang, Li-Chuan Chuang, Pei-Ching Chang   +4 more
doaj   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source