Results 61 to 70 of about 843,772 (257)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Adult oral health and dental visiting in Australia: results from the National Dental Telephone Interview Survey 2010 [PDF]

, 2013
This publication reports on the oral health, dental visiting and dental treatment needs of Australian adults as self-reported in the National Dental Telephone Interview Survey (NDTIS) 2010.
Jane Harford, Saima Islam, Harford, J.E., Islam, S.   +3 more
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Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

The effectiveness of articaine in mandibular facial infiltrations

Local and Regional Anesthesia, 2015
Dennis F Flanagan Windham Dental Group, Willimantic, CT, USA Abstract: Four percent articaine local anesthetic has been successfully used to attain local anesthesia for dental procedures. Mandibular block anesthesia may consume longer time to attain and
Flanagan DF
doaj  

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Comparative Analysis of Local Anesthetic Techniques for Pain Management in Pediatric Dental Procedures: A Randomized Clinical Trial

Journal of Pharmacy and Bioallied Sciences
Objective: The present study aims to conduct a comparative analysis of different local anesthetic techniques for pain management in pediatric dental procedures.
Ankita Dixit, Rajbir K Randhawa, Gagandeep S Randhawa, Pranav Solanki, Rimmy Takvani, Ishita Vaghela   +5 more
doaj   +1 more source

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

Impact of dental treatments under general anesthesia on oral health-related quality of life in children: a comprehensive meta-analysis

BMC Oral Health
Background Children’s oral health significantly impacts their overall well-being, daily activities, and social interactions. Dental treatments under general anesthesia are often required for extensive dental problems, special health care needs, or dental
Nasibe Aycan Yilmaz, Mehmet Emin Arayici, Candan Efeoglu   +2 more
doaj   +1 more source

Pre-school children single inhalation anesthetic exposure and neuro-psychological development: a prospective study and Mendelian randomization analysis

Frontiers in Neurology
BackgroundFor children who are unable to cooperate due to severe dental anxiety (DA), dental treatment of childhood caries under Dental General Anesthesia (DGA) is a safe and high-quality treatment method.
Jinghong Zhang, Jinghong Zhang, Jinghong Zhang, Haixia Deng, Haixia Deng, Haixia Deng, Xilu Huang, Xilu Huang, Xilu Huang, Lan Wang, Lan Wang, Lan Wang, Pinping Zhou, Jie Zeng, Jie Zeng, Jie Zeng, Cong Yu, Cong Yu, Cong Yu   +18 more
doaj   +1 more source

Department of Anesthesia. University of Iowa. Fall 2010. [PDF]

, 2010
University of Iowa Department of Anesthesia ...

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