Results 211 to 220 of about 1,112,203 (353)

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

A rapid onset of Guillain-Barre syndrome following spinal anesthesia for knee arthroscopy: a case report. [PDF]

J Med Case Rep
Kapadia AA, Koshy L, Ali U, Gupta S, Khan HN.   +4 more
europepmc   +1 more source

Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal Tissue Regeneration

Advanced Science, EarlyView.
The hollow mesoporous silica loaded with quercetin (HM‐QU@PEG) is combined with a thermosensitive anti‐bacterial matrix (TF127) to prepare HQUP@TF127. HQUP@TF127 effectively eliminates excessive ROS, alleviates endoplasmic reticulum stress, relieves mitochondrial calcium overload, and blocks the p53‐dependent apoptotic cascade. Furthermore, it enhances
Guichun Wang, Yuxiao Wang, Yang Ding, Xiang Chen, Shuhan Li, Wenqi Zhou, Rui Ma, Maomao Tang, Xinyuan Shao, Zixuan Shu, Ning He, Xiaodong Ma, Jian Guo, Chengjun Peng, Shuangying Gui   +14 more
wiley   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

The effect of isoflurane versus propofol-based total intravenous anesthesia on hemodynamic stability, intraoperative blood loss, surgical field quality, recovery characteristics, and complications in patients undergoing posterior lumbar fusion surgery: a randomized clinical trial. [PDF]

BMC Anesthesiol
Abdi A, Imani B, Zarei M, Abdolmaleki S, Zandi S, Vosough RN.   +5 more
europepmc   +1 more source

Artificial Intelligence‐Assisted Urine Cytology for Noninvasive Detection of Muscle‐Invasive Urothelial Carcinoma: A Multi‐Center Diagnostic Study with Prospective Validation

Advanced Science, EarlyView.
Accurate preoperative detection of muscle‐invasive urothelial carcinoma (MIUC) is crucial for clinical decision‐making. This study developed PUCAS‐M, an artificial intelligence (AI) model that analyzes urine cytology to assist in differentiating MIUC from non‐MIUC.
Runnan Shen, Fan Jiang, Xiaowei Huang, Guibin Hong, Yun Luo, Huan Wan, Ye Xie, Mengyi Zhu, Yun Wang, Bohao Liu, Ping Qin, Yahui Wang, Haoxuan Wang, Hongkun Yang, Zhen Lin, Rui Chen, Nengtai Ouyang, Jian Huang, Tianxin Lin, Shaoxu Wu   +19 more
wiley   +1 more source

Effect of different doses of intravenous dexmedetomidine as an adjunct to the serratus anterior plane block in patients undergoing modified radical mastectomy: a randomized controlled trial. [PDF]

Ann Med
Huang L, Zhao S, Zhu W, Zhu X, Pan L, Wang Q, Shi K.   +6 more
europepmc   +1 more source

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

Advanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang, Wenye Wang, Yidong Peng, Weiji Weng, Hanyu Wei, Qiyuan Feng, Antian Wang, Minjie Hu, Zhuoran Li, Shenyu Sun, Zhenghui He, Daiwen Zhang, Wenlan Qi, Yuhan Han, Zixuan Ma, Jiyuan Hui, Ru Gong, Yingwei Gao, Yong Lin, Jiyao Jiang, Xiaoling Gao, Junfeng Feng   +21 more
wiley   +1 more source

A nomogram predicting the risk of postoperative pneumonia after esophagectomy in esophageal carcinoma. [PDF]

Front Med (Lausanne)
Chen B, Ke W, Li M.
europepmc   +1 more source

Paravertebral blocks and enhanced recovery after surgery protocols in breast reconstructive surgery: Patient selection and perspectives [PDF]

, 2018
Myckatyn, Terence M, Parikh, Rajiv P
core   +1 more source