Results 121 to 130 of about 531,326 (305)

Apprehension of paraplegia after undergoing spinal anesthesia in the central region population of Saudi Arabia: A cross-sectional study

Journal of Pharmacy and Bioallied Sciences
Aim: The aim of the present study was to determine the prevalence of paraplegia-related fear in spinal anesthesia among the general population in the central region of Saudi Arabia.
Faris Suleiman Saleh Aldobekhi, Manal M Almutairi, Mohammed H Alanazi, Badah M Aldawsari, Sarah S Almutairi, Abdulkarim K Alenazi, Abdulazizludba N Binmuhareb, Ghadi A Alfadhil, Shouq Y Alaoufi, Abdullah O Alqahtani   +9 more
doaj   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Local versus Spinal Anesthesia for Endovenous Ablation Therapy: A Comparative Study

Cerrahpaşa Medical Journal
  Objective: Endovenous thermal ablation techniques such as endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) are widely used in the treatment of chronic venous insufficiency.
Berk Arapi, Çiğdem Tel Üstünışık, Ozan Onur Balkanay, Elif Çiftçi, Nevzat Cem Sayılgan, Serkan Burç Deşer, Deniz Göksedef, Suat Nail Ömeroğlu, Gökhan İpek   +8 more
doaj   +1 more source

Foot drop after spinal anesthesia for cesarean section: a case report

, 2018
Ali Dastkhosh,1 Majid Razavi,2 Mehryar Taghavi Gilani2 1Mashhad University of Medical Sciences, Mashhad, Iran; 2Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Objective: Spinal anesthesia is the preferred anesthetic ...
Dastkhosh A, Razavi M, Taghavi Gilani M
core  

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

A comparative Study on the effectiveness of Tramado and Meperidine in treatment of perioperative patient with shivering undergoing casarean section with spinal anesthesia [PDF]

Backgrond & Objectives: Perioperartive shivering is a common complication which interferes with monitoring of patients and it increases oxygen consumption (up to 500%) which can be life-threating in patients with a low cardio pulmonary reserve.
محمدیان اردی, علی, منوچهریان, ناهید   +1 more
core  

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Case report: management of differential diagnosis and treatment of severe anaphylaxis in the setting of spinal anesthesia

, 2016
The purpose of this case report is to educate fellow anesthesiologists of a complicated differential diagnosis for sudden cardiovascular collapse after spinal anesthesia.
Osman, Brian M, Baquero, Sebastian M, Maga, Joni M   +2 more
core   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source