Results 241 to 250 of about 1,034,377 (353)

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Ciprofol vs Propofol for Intraoperative Neurophysiological Monitoring in Elderly Patients Undergoing Spinal Surgery: A Randomized Controlled Trial. [PDF]

Drug Des Devel Ther
Fan G, Hu Z, Zheng S, Chen S, Yi K, Yin S, Sun W.   +6 more
europepmc   +1 more source

Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain

Developmental Dynamics, EarlyView.
Abstract Background In mammals, specific brain regions such as the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles harbor adult neural stem/progenitor cells (ANSPCs) that give rise to new neurons and contribute to structural and functional brain plasticity.
Diana Zhilina, Lizbeth A. Bolaños Castro, Juan Sebastian Eguiguren, Sara Zocher, Anne Karasinsky, Dimitri Widmer, Alexandre Espinós, Victor Borrell, Michael Brand, Kyoko Miura, Oliver Zierau, Maximina H. Yun, Tomohisa Toda   +12 more
wiley   +1 more source

Anesthetic Considerations for Cesarean Section in a Woman With Systemic Mastocytosis. [PDF]

Cureus
Phipps W, Richardson L, Jolly E.
europepmc   +1 more source

Sarcoidosis revealed by recurrent dactylitis.

Arthritis &Rheumatology, Accepted Article.
Thomas Subervie, Thibault Willaume, Amin Maazouzi, Jacques‐Eric Gottenberg, Jean Sibilia, Noëlle Weingertner, Eden Sebbag, Marc Scherlinger   +7 more
wiley   +1 more source

The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous system regeneration, was used to examine the role of the endocannabinoid system in the regeneration of the tail and spinal ...
Michael Tolentino, Sarah E. Walker, Gaynor E. Spencer, Robert Carlone   +3 more
wiley   +1 more source

Continuous spinal anesthesia in a case of Eisenmenger syndrome undergoing TURBT- A case report. [PDF]

Saudi J Anaesth
Ahmed HM.
europepmc   +1 more source

Embryonic cerebrospinal fluid pressure in fetal mice in utero: External factors pressurize the intraventricular space

Developmental Dynamics, EarlyView.
Abstract Background Previous experiments inducing leakage of embryonic cerebrospinal fluid (CSF) suggest the necessity of intraventricular CSF pressure (PCSF) for brain morphogenesis. Nevertheless, how embryonic PCSF occurs is unclear, especially in utero. Results Using a Landis water manometer, we measured PCSF in fetal mice isolated from the amniotic
Koichiro Tsujikawa, Reina Muramatsu, Takaki Miyata   +2 more
wiley   +1 more source

Outcomes of Transurethral Resection of the Prostate (TURP) in High-Risk Cardiac Patients Under Spinal Anesthesia. [PDF]

Cureus
Mehmood Z, Abdullah MA, Sanan M, Fayyaz H, Ahmad U, Iftikhar A, Aslam F, Pervaiz Khanday S.   +7 more
europepmc   +1 more source