EFEK PEMBERIAN ONDANSETRON INTRAVENA TERHADAP TEKANAN DARAH DAN LAJU NADI PASIEN BEDAH ELEKTIF DENGAN ANESTESI SPINAL DI RSUD RADEN MATTAHER JAMBI [PDF]
, 2023 Background: Spinal anesthesia is most commonly performed anesthetic technique around the world. Hypotension and bradycardia are the most common side effect that related to spinal anesthesia. Recently, Ondansetron as a serotonin receptor antagonists, have
Aldaherlen Kalkarina +2 more
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MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer
Advanced Science, EarlyView.This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang +9 more
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Advanced Science, EarlyView.How locus coeruleus noradrenergic‐spinal projections and subsequent α2A adrenoceptors‐CaMKII signaling cascades contribute to electroacupuncture‐induced antinociception in postoperative pain in mice is described. Abstract Postoperative pain remains a significant challenge in healthcare.
Wen‐Guang Chu +13 more
wiley +1 more source
Contrast Agent Clearance Dynamics and Diffusion in the Mouse Brain After Ventricular Administration
Advanced Science, EarlyView.Schematic representation of contrast agent clearance by convective bulk flow from the ventricular spaces to the subarachnoid space on the ventral aspect of the brain, or by diffusion into the parenchyma across the pia‐glia or through the semi‐permeable ependyma. Abstract Fluid and solute exchange between cerebrospinal fluid (CSF) spaces and the central
Yann Decker +2 more
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Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain
Advanced Science, EarlyView.Ce‐UiO‐66‐Bupivacaine (CUB) demonstrates triple therapeutic innovation: 1) Sustained analgesia with ROS scavenging synergistically resolves neuropathic pain; 2) Microglia/astrocyte polarization switch reprograms the pro‐regenerative immune microenvironment; 3) CGRP‐TSP‐1 axis activation couples inflammation suppression to axon regeneration, defining a ...
Yue Wang +9 more
wiley +1 more source
The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression
Advanced Science, EarlyView.LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao +7 more
wiley +1 more source
Advanced Science, EarlyView.This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv +8 more
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Ketamine infusion induces urinary retention in a patient successfully treated by sacral neuromodulation [PDF]
, 2017 A
Devulder, Jacques +3 more
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Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke
Advanced Science, EarlyView.Delayed transplantation of human iPSC‐derived neural progenitor cells (NPCs) enhances graft survival, proliferation, and axonal sprouting after stroke. Using bioluminescence imaging and histology in a mouse model of stroke, it is shown that NPC delivery at 7 days post‐stroke is more effective than acute transplantation, highlighting the importance of ...
Rebecca Z Weber +6 more
wiley +1 more source
Dejeneratif spondilolistezis, spinal stenoz, lomber kompresyon fraktürü olan yüksek riskli hastalarda spinal anestezi ile posterior lomber stabilizasyon cerrahisi [PDF]
, 2015 AIm: Spinal anesthesia is an appropriate technique for lumbar spine surgeries of two to three hours duration. The aim of this study is todocument our experience on spinal anesthesia administered to the patients with degenerative lumbar spine.Ma terIal ...
Bengisun, Züleyha Kazak +4 more
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