Results 81 to 90 of about 354,161 (341)

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li   +5 more
wiley   +1 more source

Trends and Emerging Research Areas in Postoperative Sleep Disturbances: A Bibliometric Analysis

open access: yesNature and Science of Sleep
Wei Du, Xi Qiao, Wei Liu, Chao Li, Huiqun Jia Department of Anesthesiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, People’s Republic of ChinaCorrespondence: Huiqun Jia, The Fourth Hospital of Hebei Medical ...
Du W, Qiao X, Liu W, Li C, Jia H
doaj  

Do Complexity Measures of Frontal EEG Distinguish Loss of Consciousness in Geriatric Patients Under Anesthesia? [PDF]

open access: yes, 2018
While geriatric patients have a high likelihood of requiring anesthesia, they carry an increased risk for adverse cognitive outcomes from its use. Previous work suggests this could be mitigated by better intraoperative monitoring using indexes defined by
Caitlin M. Drover   +8 more
core   +2 more sources

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

open access: yesAdvanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei   +10 more
wiley   +1 more source

Model-Informed Precision Dosing of Remimazolam in General Anesthesia Patients

open access: yesDrug Design, Development and Therapy
Yueting Chen,1,* Zuo-Jing Zhang,2,* Xiao-Feng Zhang,2 Yuan Peng,2 Zheng Jiao,1,* Jing-Xiang Wu2,* 1Department of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s ...
Chen Y   +5 more
doaj  

Supplemental peri-operative intravenous crystalloids for postoperative nausea and vomiting: an abridged Cochrane systematic review. [PDF]

open access: yes, 2020
We conducted a Cochrane systematic review on the effectiveness of supplemental intravenous crystalloid administration in preventing postoperative nausea and vomiting.
Bird, SJ   +5 more
core  

Obstructive sleep apnea as an independent predictor of postoperative delirium and pain: Protocol for an observational study of a surgical cohort [version 2; referees: 2 approved] [PDF]

open access: yes, 2018
Introduction: Postoperative delirium and pain are common complications in adults, and are difficult both to prevent and treat. Obstructive sleep apnea (OSA) is prevalent in surgical patients, and has been suggested to be a risk factor for postoperative ...
Arrington, Brianna   +7 more
core   +2 more sources

Hepatocyte‐Specific GSDMD Deficiency Aggravates Sepsis by Disrupting Non‐Canonical Secretion of Anti‐Inflammatory Factors

open access: yesAdvanced Science, EarlyView.
This study proposes for the first time that hepatic GSDMD plays a key protective role in sepsis. Hepatic GSDMD may release inflammatory inhibitory factors including VEGF‐B and Gremlin‐1 through pore‐forming activity to inhibit the production of inflammatory factors from macrophages, thereby alleviating the inflammatory response of septic mice ...
Yihan Qian   +9 more
wiley   +1 more source

Air quality and employee hygiene-related behavior in a post anesthesia care unit in Thailand

open access: yesAsian/Pacific Island Nursing Journal, 2019
Post anesthesia care units (PACU) are sanitary spaces at hospitals. Bacterial and fungal contaminants in ambient air can pose significant threats to patient recovery.
Somphorn Kampan
doaj   +1 more source

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