Results 41 to 50 of about 120,869 (308)
Advanced Science, EarlyView.The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang +7 more
wiley +1 more source
Journal of Pain Research, 2023 Timothy Deer,1 Alaa Abd-Elsayed,2 Krishnan Chakravarthy,3 Joshua M Rosenow,4 Steven Falowski,5 Erika Petersen,6 Julie Pilitsis,7 Corey Hunter,8 Dawood Sayed,9 Michael E Schatman10,11 1The Spine and Nerve Center of the Virginias, Charleston, WV, USA ...
Deer T +9 more
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Expression of vesicular glutamate transporters in sensory and autonomic neurons innervating the mouse urinary bladder [PDF]
, 2013 Purpose: Vesicular glutamate transporters (VGLUTs), essential for loading glutamate into synaptic vesicles, are present in various neuronal systems. However, the expression of VGLUTs in neurons innervating the urinary bladder has not yet been analyzed ...
Brumovsky, Pablo Rodolfo +5 more
core +2 more sources
Advanced Science, EarlyView.This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao +13 more
wiley +1 more source
Managing Prolonged Pain After Surgery: Examining the Role of Opioids. [PDF]
, 2018 A notable minority of patients experience persistent postsurgical pain and some of these patients consequently have prolonged exposure to opioids. Risk factors for prolonged opioid use after surgery include preoperative opioid use, anxiety, substance ...
Pozek, John-Paul J. +2 more
core +1 more source
Effects of Modification of Pain Protocol on Incidence of Post Operative Nausea and Vomiting. [PDF]
, 2016 BackgroundA Perioperative Surgical Home (PSH) care model applies a standardized multidisciplinary approach to patient care using evidence-based medicine to modify and improve protocols.
Ahn, Kyle +7 more
core +2 more sources
Advanced Science, EarlyView.Resorbable impedance sensors are successfully implanted into porcine small intestinal anastomoses. Impedance was recorded for 2 hours prior, and 2 hours following ischemia induction, and a significant drop in tissue impedance was observed. Abstract Anastomotic failure remains one of the most severe complications in gastrointestinal surgery.
Dennis Wahl +12 more
wiley +1 more source
Advanced Science, EarlyView.The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li +10 more
wiley +1 more source
Do Complexity Measures of Frontal EEG Distinguish Loss of Consciousness in Geriatric Patients Under Anesthesia? [PDF]
, 2018 While geriatric patients have a high likelihood of requiring anesthesia, they carry an increased risk for adverse cognitive outcomes from its use. Previous work suggests this could be mitigated by better intraoperative monitoring using indexes defined by
Caitlin M. Drover +8 more
core +2 more sources
Advanced Science, EarlyView.All‐hydrogel based n‐type depletion‐mode OECTs is developed using a semiconductor hydrogel formed via ionic‐liquid‐mediated phase separation, combining efficient ion‐electron transport, tissue‐like softness, and long‐term biocompatibility. The device can monitor EOG and ECG on human skin and record real‐time ECG subcutaneously in rats, providing a ...
Qicheng Liang +14 more
wiley +1 more source