Results 41 to 50 of about 2,711,128 (308)

A data science approach to drug safety: Semantic and visual mining of adverse drug events from clinical trials of pain treatments [PDF]

Artificial Intelligence in Medicine 2021;115:102074, 2020
Clinical trials are the basis of Evidence-Based Medicine. Trial results are reviewed by experts and consensus panels for producing meta-analyses and clinical practice guidelines. However, reviewing these results is a long and tedious task, hence the meta-analyses and guidelines are not updated each time a new trial is published.
arxiv   +1 more source

Parametric study of lumbar belts in the case of low back pain: effect of patients' specific characteristics [PDF]

Computational Biomechanics for Medicine, Springer International Publishing, pp.43-59, 2020, 2020
Objective: A numerical 3D model of the human trunk was developed to study the biomechanical effects of lumbar belts used to treat low back pain. Methods: This model was taken from trunk radiographies of a person and simplified so as to make a parametric study by varying morphological parameters of the patient, characteristic parameters of the lumbar ...
arxiv   +1 more source

Serious Issues in Authorship, Design, and Conclusions of JAMA Neurology Real-World Evidence Study on Spinal Cord Stimulation Outcomes and Costs as Compared to Conventional Medical Therapy

Journal of Pain Research, 2023
Timothy Deer,1 Alaa Abd-Elsayed,2 Krishnan Chakravarthy,3 Joshua M Rosenow,4 Steven Falowski,5 Erika Petersen,6 Julie Pilitsis,7 Corey Hunter,8 Dawood Sayed,9 Michael E Schatman10,11 1The Spine and Nerve Center of the Virginias, Charleston, WV, USA ...
Deer T, Abd-Elsayed A, Chakravarthy K, Rosenow JM, Falowski S, Petersen E, Pilitsis J, Hunter C, Sayed D, Schatman ME   +9 more
doaj  

Clustering of Pain Dynamics in Sickle Cell Disease from Sparse, Uneven Samples [PDF]

arXiv, 2021
Irregularly sampled time series data are common in a variety of fields. Many typical methods for drawing insight from data fail in this case. Here we attempt to generalize methods for clustering trajectories to irregularly and sparsely sampled data. We first construct synthetic data sets, then propose and assess four methods of data alignment to allow ...
arxiv  

Pain Education and Knowledge (PEAK) Consensus Guidelines for Neuromodulation: A Proposal for Standardization in Fellowship and Training Programs

Journal of Pain Research, 2023
Scott G Pritzlaff,1 Johnathan H Goree,2 Jonathan M Hagedorn,3 David W Lee,4 Kenneth B Chapman,5 Sandy Christiansen,6 Andrew Dudas,7 Alexander Escobar,8 Christopher J Gilligan,9 Maged Guirguis,10 Amitabh Gulati,11 Jessica Jameson,12 Christopher J Mallard ...
Pritzlaff SG, Goree JH, Hagedorn JM, Lee DW, Chapman KB, Christiansen S, Dudas A, Escobar A, Gilligan CJ, Guirguis M, Gulati A, Jameson J, Mallard CJ, Murphy M, Patel KV, Patel RG, Sheth SJ, Vanterpool S, Singh V, Smith G, Strand NH, Vu CM, Suvar T, Chakravarthy K, Kapural L, Leong MS, Lubenow TR, Abd-Elsayed A, Pope JE, Sayed D, Deer TR   +30 more
doaj  

Statistical Applications in Pain Management: A Review [PDF]

arXiv, 2023
Chronic pain is a widespread and debilitating condition that affects millions of individuals worldwide. Recent research has unveiled a connection between chronic pain and epigenetic processes, shedding light on the complex interplay between genetics, environment, and pain perception.
arxiv  

Effects of Pharmacologic and Nonpharmacologic Interventions for the Management of Sleep Problems in People With Fibromyalgia: Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials

Arthritis Care &Research, EarlyView.
Objective Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain and fatigue. Almost everyone with fibromyalgia has sleep problems. We aimed to evaluate the effectiveness and safety of current interventions for the management of fibromyalgia‐related sleep problems.
Jemma Hudson, Mari Imamura, Clare Robertson, Daniel Whibley, Lorna Aucott, Katie Gillies, Paul Manson, Debra Dulake, Abhishek Abhishek, Nicole K. Y. Tang, Gary J. Macfarlane, Miriam Brazzelli   +11 more
wiley   +1 more source

Measuring Pain in Sickle Cell Disease using Clinical Text [PDF]

arXiv, 2020
Sickle Cell Disease (SCD) is a hereditary disorder of red blood cells in humans. Complications such as pain, stroke, and organ failure occur in SCD as malformed, sickled red blood cells passing through small blood vessels get trapped. Particularly, acute pain is known to be the primary symptom of SCD.
arxiv  

Preoperative Prognosis Assessment of Lumbar Spinal Surgery for Low Back Pain and Sciatica Patients based on Multimodalities and Multimodal Learning [PDF]

arXiv, 2023
Low back pain (LBP) and sciatica may require surgical therapy when they are symptomatic of severe pain. However, there is no effective measures to evaluate the surgical outcomes in advance. This work combined elements of Eastern medicine and machine learning, and developed a preoperative assessment tool to predict the prognosis of lumbar spinal surgery
arxiv  

A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis

Advanced Science, EarlyView.
The circRNA circNAB1 is downregulated in AF patient. Silencing circNAB1 promotes collagen deposition and inflammation, whereas overexpression reduces AF susceptibility. circNAB1 encodes the protein NAB1 356 that interacts with EGR1 to mitigate fibrosis and inflammation.
William W Du, Muhammad Rafiq, Hui Yuan, Xiangmin Li, Sheng Wang, Jun Wu, Jinfeng Wei, Ren‐Ke Li, Huiming Guo, Burton B Yang   +9 more
wiley   +1 more source