Results 111 to 120 of about 343,216 (264)

Local anesthetic systemic toxicity: current perspectives

Local and Regional Anesthesia, 2018
Kariem El-Boghdadly,1,2 Amit Pawa,1 Ki Jinn Chin3 1Department of Anaesthesia, Guy’s and St Thomas’ NHS Foundation Trust, London, UK; 2School of Medicine, King’s College London, London, UK; 3Department of Anesthesia, Toronto Western ...
El-Boghdadly K, Pawa A, Chin KJ
doaj  

Photonic Nanomaterials for Wearable Health Solutions

Advanced Materials, EarlyView.
This review discusses the fundamentals and applications of photonic nanomaterials in wearable health technologies. It covers light‐matter interactions, synthesis, and functionalization strategies, device assembly, and sensing capabilities. Applications include skin patches and contact lenses for diagnostics and therapy. Future perspectives emphasize AI‐
Taewoong Park, Jung Woo Leem, Young L. Kim, Chi Hwan Lee   +3 more
wiley   +1 more source

3D transcranial Dynamic Ultrasound Localization Microscopy in the mouse brain using a Row-Column Array [PDF]

arXiv
The role of brain hemodynamics in neurodegenerative diseases cannot be fully assessed using existing imaging technologies. Recently, 2D Dynamic Ultrasound Localization Microscopy (DULM) has allowed for the quantitative mapping of the pulsatile flow at sub-wavelength resolution. However, to obtain accurate velocity estimates, 3D imaging is more adapted,
arxiv  

Transparent Temperature Sensors for Photothermal Neuromodulation: Advances, Challenges, and Future Directions

Advanced Materials Interfaces, EarlyView.
Photothermal neuromodulation is a promising technique for versatile neural signal study and treatment development. To further develop these technologies and optimize their effectiveness, transparent electrical temperature sensors with high thermal sensitivity and resolution are essential for accurately monitoring temperature changes during ...
Jee Woong Lee, Junhee Lee, Jungha Lee, Duhee Kim, Woongki Hong, Junghyup Lee, Minyoung Song, Hongki Kang   +7 more
wiley   +1 more source

A Flexible‐Substrate 5‐µm‐Diameter Needle Electrode: Minimizing Neuronal Death and Enabling Year‐Long Neural Recording

Advanced Materials Interfaces, EarlyView.
An electrophysiological recording technology that uses a 5‐µm‐diameter microneedle electrode device is presented. Due to the remarkable small dimension of the microneedle, the electrode provides minimal invasive neural recording in a mouse brain and enables long‐term recording exceeding the year‐long duration.
Hinata Sasaki, Koji Yamashita, Sayaki Shimizu, Kensei Sakamoto, Rika Numano, Kowa Koida, Takeshi Kawano   +6 more
wiley   +1 more source

Assessing the Safety Margin for Micromotion‐Induced Strain at Electrode–Tissue Interface: A Finite Element Analysis via COMSOL

Advanced Materials Interfaces, EarlyView.
Brain movement significantly impacts the biocompatibility of neural probes due to continuous strain on neural tissue. This study examines strain profiles across various brain models and movement types, challenging the 5% damage threshold at the electrode–tissue interface.
Ali Sharbatian, Akhilesh Kamtikar, Danesh Ashouri Vajari, Thomas Stieglitz   +3 more
wiley   +1 more source

Advances in the use of local anesthetic extended-release systems in pain management

Drug Delivery
Pain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management.
Yulu Chen, Jingmei Xu, Ping Li, Liyang Shi, Sha Zhang, Qulian Guo, Yong Yang   +6 more
doaj   +1 more source

Multi-Agent Deep Reinforcement Learning for Multiple Anesthetics Collaborative Control [PDF]

arXiv
Automated control of personalized multiple anesthetics in clinical Total Intravenous Anesthesia (TIVA) is crucial yet challenging. Current systems, including target-controlled infusion (TCI) and closed-loop systems, either rely on relatively static pharmacokinetic/pharmacodynamic (PK/PD) models or focus on single anesthetic control, limiting ...
arxiv  

Ultra‐Flexible µ‐ECoG Arrays Based on PEDOT:PSS Micropillars

Advanced Materials Interfaces, EarlyView.
This work demonstrates an efficient procedure for fabricating ultra‐flexible neural interfaces endowed with micropatterned microelectrodes to increase surface area and characterized by extremely low impedance values to enable high‐quality recordings. The home‐built device has been shown to record somatosensory evoked potentials in vivo with exceptional
Alice Lunghi, Michele Bianchi, Pierpaolo Greco, Riccardo Viaro, Michele Di Lauro, Luciano Fadiga, Fabio Biscarini   +6 more
wiley   +1 more source

Biological and Mechanical Limitations for Chronic Fast‐Scan Cyclic Voltammetry Sensor Design

Advanced Materials Technologies, EarlyView.
Real‐time detection of neurochemicals has demonstrated value in the field of neuroscience. However, current methods have limitations for use in the chronic setting, which is often the ideal environment for research. This article discusses these limitations, as well as technologies that have been developed to overcome them, and provides recommendations ...
Mason L. Perillo, Bhavna Gupta, Akash Saxena, Alexandra P. Veltri, Wen Li, James R. Siegenthaler, Erin K. Purcell   +6 more
wiley   +1 more source