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Local Anesthetics

2006
Local anesthetics are drugs used in many different ways and in various situations requiring local pain relief, beginning with simple procedures, such as removing a small piece of the outer layer of damaged skin, to complicated operations, such as organ transplantations.
V.J. Hruby, R.S. Vardanyan
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Allergy to Local Anesthetics

JAMA: The Journal of the American Medical Association, 1969
Patients frequently relate a history suggesting allergy to local anesthetic drugs which have been commonly recognized as causing dermatitis and systemic reactions. 1 However, there appears to be a wide discrepancy between the actual incidence and the emphasis placed on them by textbooks and lectures.
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Local Anesthetics

2014
The Side Effects of Drugs Annuals form a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. The series supplements the contents of Meyler's Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and Interactions. This review of relevant publications from January 2012 to June 2013
Sekandarzad, Mir Wais, Schug, Stephan A.
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Reactions to Local Anesthetics

JAMA: The Journal of the American Medical Association, 1966
Local anesthetics are used widely by practically all physicians, most of whom are not fully aware of the lethal potential of local anesthetics and the swiftness with which they may precipitate a catastrophe. The perineural concentration of a local anesthetic necessary to interrupt conduction in a nerve fiber is many times greater than that which a ...
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Local Anesthetic Agents

Emergency Medicine Clinics of North America, 1988
The rational selection and safe use of local anesthetic solutions is of paramount importance to the practice of emergency medicine. Such decisions are based on a sound knowledge of the pharmacology and toxicity of those agents one uses clinically in day to day practice.
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Choosing a Local Anesthetic

Dermatologic Clinics, 1994
Although lidocaine alone will serve as an excellent anesthetic for most patients, using less painful injectable agents, topical anesthetics, and occasionally oral sedation will offer the frightened or pain-intolerant patient an acceptable and effective alternative system of local anesthesia.
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Local Anesthetics: Eutectic Mixture of Local Anesthetics

1991
All commonly available local anesthetics have poor skin penetration when applied topically. One of the main reasons is that a local anesthetic agent needs to be in its cationic form in order to block nerve conduction. But it is the uncharged base which penetrates and diffuses into the tissues after topical administration.
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THE PHARMACOLOGY OF LOCAL ANESTHETICS

Anesthesiology Clinics of North America, 2000
The pharmacology of local anesthetics is an integration of the basic physiology of excitable cells and the mechanism by which local anesthetics are capable of interrupting conduction of neural messages. The common characteristics of the molecules with local anesthetic action have been identified and can explain the properties of the agents.
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LOCAL ANESTHETICS

The Journal of the American Dental Association, 2013
David B. Auyong, Francis V. Salinas
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Narcotics and Local Anesthetics

Veterinary Clinics of North America: Equine Practice, 1993
The recognition and alleviation of animal pain is a growing veterinary and public concern. Pain can be of an acute or chronic nature with different behavioral manifestations. Physiologically, pain is a dynamic and complex phenomenon that produces changes in the central and autonomic nervous systems as well as in the endocrine system.
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