Results 31 to 40 of about 145,398 (290)
The challenge of evaluating pain and a pre-incisional local anesthetic block. [PDF]
, 2014 Background. Our objective was to test the effectiveness of a local anesthetic line block administered before surgery in reducing postoperative pain scores in dogs undergoing ovariohysterectomy (OVHX). Methods.
Kass, Philip H +3 more
core +2 more sources
Interacting Turing-Hopf Instabilities Drive Symmetry-Breaking Transitions in a Mean-Field Model of the Cortex: A Mechanism for the Slow Oscillation [PDF]
, 2013 Electrical recordings of brain activity during the transition from wake to anesthetic coma show temporal and spectral alterations that are correlated with gross changes in the underlying brain state. Entry into anesthetic unconsciousness is signposted by
Sleigh, James W. +2 more
core +3 more sources
THE PHARMACOLOGY OF THE LOCAL ANESTHETICS [PDF]
Journal of the American Medical Association, 1919 Acute intoxication in man from the use of the local anesthetics is far more common than is indicated by the number of recorded cases. We undertook to investigate the causes of such intoxication, and sought to find means of avoiding it, or combating it when it arises.
Robert A. Hatcher, Cary Eggleston
openaire +2 more sources
Indian Journal of Pain, 2014 Aim: The aim of this study was to evaluate and compare the Pain Perception and Procedural Tolerance (PPPT) by the pediatric patients, while experiencing ′Computer Controlled Local Anesthetic Technique′ (CCLAD, Wand) and ′Conventional local anesthetic ...
Rahul Goyal, B Nandlal, Prashanth
doaj +1 more source
Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]
, 2008 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A. +3 more
core +2 more sources
BMC Anesthesiology, 2019 Background Continuous epidural infusion (CEI) has some disadvantages, such as increased local anesthetic consumption and limited area of anesthetic distribution.
M. Higashi +4 more
doaj +1 more source
Successful lipid rescue of local anesthetic systemic toxicity following peribulbar block
Medical Journal of Dr. D.Y. Patil University, 2015 Local anesthesia is commonly used to perform cataract surgery. We present a case in which local anesthesia systemic toxicity, which occurred after peribulbar block.
Vinayak S Pujari +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
FEBS Open Bio, EarlyView.Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr +5 more
wiley +1 more source
Topical anesthetic versus lidocaine infiltration in arteriovenous fistula cannulation
CHRISMED Journal of Health and Research, 2014 Background: End stage renal disease (ESRD) patients on maintenance hemodialysis undergo arterio-venous fistula (AVF) cannulation prior to each hemodialysis session for blood access.
Anisha George +6 more
doaj +1 more source