Results 91 to 100 of about 6,460,264 (307)

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Single injection thoracic paravertebral block (TPVB) for breast surgery in morbidly obese patient

Asian Journal of Oncology, 2017
Morbidly obese (MO) patients with associated restrictive airway disease, obstructive sleep apnea, and coronary artery disease pose challenge to an anesthesiologist.
Anita Kulkarni, Vedapadmapriya Selvakumar, Namrata Gupta   +2 more
doaj   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Bupivacaína 0,15% hipobárica versus lidocaína 0,6% hipobárica para raquianestesia posterior em cirurgia anorretal ambulatorial Bupivacaína 0,15% hipobárica versus lidocaína 0,6% hipobárica para raquianestesia posterior en cirugía anorrectal ambulatorial Hypobaric 0.15% bupivacaine versus hypobaric 0.6% lidocaine for posterior spinal anesthesia in outpatient anorectal surgery

Revista Brasileira de Anestesiologia, 2010
JUSTIFICATIVA E OBJETIVOS: Baixas doses de bupivacaína e lidocaína têm sido usadas para raquianestesia em cirurgia ambulatorial. O objetivo deste estudo foi comparar a bupivacaína com a lidocaína ambas em solução hipobárica em pacientes ambulatoriais de ...
Luiz Eduardo Imbelloni, Marildo A Gouveia, José Antonio Cordeiro   +2 more
doaj   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Rectus sheath block as the sole anesthesia technique for open surgical repair of umbilical hernias: A retrospective cohort study

Saudi Journal of Anaesthesia
Background: The rectus sheath block is a regional anesthetic technique that provides effective analgesia for midline abdominal surgeries. This study evaluated the feasibility of the rectus sheath block as the sole anesthetic technique for open umbilical ...
Emma L. Rispler, David L. Bettan, Alexander Valerio, Sean D. Jeffries, Avinash Sinha, Thomas M. Hemmerling   +5 more
doaj   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Quadratus lumborum block as a component of analgesia in laparoscopic cholecystectomy

Медицина неотложных состояний
Laparoscopic cholecystectomy is a minimally invasive procedure. However, it can cause severe postoperative pain, and sometimes chronic pain. This pain results from several causes: trocar insertion, wound healing, surgical manipulation with the ...
S.M. Chooklin, S.S. Chuklin
doaj   +1 more source

Anesthetic Considerations: Local Versus Regional

, 2011
Local anesthesia is defined as a loss in the perception of pain over a small area of the body. Regional anesthesia is also a loss in the perception of pain, but in a larger anatomical area or region.
Alqubaisy, Yasser A, Choudhary, Sonal, Sonal Choudhary, McLeod, Michael P, Nouri, Keyvan, Michael P. McLeod, Yasser A. Alqubaisy, Keyvan Nouri   +7 more
core   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source