Results 131 to 140 of about 15,845 (267)

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

open access: yesAging Cell, EarlyView.
Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik   +20 more
wiley   +1 more source

Neurological Deficits Following Regional Anesthesia and Pain Interventions: Reviewing Current Standards of Care. [PDF]

open access: yesPain Ther
El-Tallawy SN   +10 more
europepmc   +1 more source

Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia‐Dependent Plaque Response in Aged Mice

open access: yesAging Cell, EarlyView.
This study shows that human and mouse brains contain a different pool of strains that differentially affect the formation of Aβ and tau aggregates. Moreover, the murine seeds trigger an unresponsiveness microglial state, which causes the loss of plaque microglial coverage and affects the formation of amyloid plaques, leading to more severe neuritic ...
Juana Andreo‐Lopez   +20 more
wiley   +1 more source

Regional anaesthesia for awake urgent upper limb surgery in children: a prospective cohort study

open access: yesAnaesthesia, EarlyView.
Summary Introduction Peripheral regional anaesthesia is used rarely as the sole anaesthetic technique in children and is often combined with deep sedation or general anaesthesia for analgesic purposes. No literature addresses the minimum age at which regional anaesthesia can be considered to facilitate awake surgery in children.
Olivier Maupain   +8 more
wiley   +1 more source

Impact of tracheal extubation location after surgical procedures on peri‐operative times: a prospective dual‐centre observational study*

open access: yesAnaesthesia, EarlyView.
Summary Introduction Extubation of the trachea in the operating theatre may increase the time spent there. Conversely, tracheal extubation in the post‐anaesthesia care unit may prolong the duration of anaesthesia and increase the incidence of complications.
Thomas Godet   +13 more
wiley   +1 more source

Airway management in patients living with obesity: best practice recommendations from the Society for Obesity and Bariatric Anaesthesia

open access: yesAnaesthesia, EarlyView.
Summary Introduction Patients living with obesity present specific challenges for airway management. They have been overrepresented repeatedly in studies looking at complications associated with airway management. Whilst generic airway guidelines offer assistance, there are no evidence‐based guidelines specific to this group of patients to support safe
Andrew McKechnie   +7 more
wiley   +1 more source

Fascial plane blocks as the main anesthetic method: A narrative review. [PDF]

open access: yesSaudi J Anaesth
Tulgar S   +6 more
europepmc   +1 more source

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