Results 101 to 110 of about 548,111 (319)

Biomimetic Nanoplatform for Targeted Rheumatoid Arthritis Therapy: Modulating Macrophage Niches Through Self‐Sustaining Positive Feedback‐Driven Drug Release Mechanisms

Advanced Science, EarlyView.
Rheumatoid arthritis is an incurable inflammatory autoimmune disease. The cleverly biomimetic nanoplatform integrates nanoenzymes and gene therapeutics and is sequentially modified by guanidinium‐based polymers and macrophage membranes, enhancing the gene silencing capability and reactive oxygen species scavenging efficiency through self‐sustaining ...
Huichao Xie, Xiaoyu Huang, Bao Li, Yongfeng Chen, Haoran Niu, Tong Yu, Shimei Yang, Shuxin Gao, Yutong Zeng, Tianzhi Yang, Yan Kang, Keda Zhang, Pingtian Ding   +12 more
wiley   +1 more source

Efeito da adição de clonidina subaracnóidea à solução anestésica de sufentanil e bupivacaína hiperbárica ou hipobárica para analgesia de parto Efecto de la adición de clonidina subaracnoidea a la solución anestésica de sufentanil y bupivacaína hiperbárica o hipobárica para la analgesia de parto Effects of the addition of subarachnoid clonidine to the anesthetic solution of sufentanil and hyperbaric or hypobaric bupivacaine for labor analgesia

Revista Brasileira de Anestesiologia, 2008
JUSTIFICATIVA E OBJETIVOS: Adição de clonidina subaracnóidea (±-agonista) prolonga a ação analgésica da combinação sufentanil e bupivacaína isobárica em analgesia combinada para o trabalho de parto ¹.
Thaís Cristina Tebaldi, Luíz Marcelo Sá Malbouisson, Mario. M Kondo, Mônica M. S. C. Cardoso   +3 more
doaj   +1 more source

Dynamic Pathophysiological Insight into the Brain by NIR‐II Imaging

Advanced Science, EarlyView.
The functional integration of benefits from small semiconducting dyes and biocompatible serum proteins ushered in a new frontier of deep wide‐field in vivo imaging technique, affording valuable pathophysiological insight into the functioning of neurovascular unit in space and time.
Si Chen, Hao Chen, Xinxin Li, Shuqing He, Kangquan Shou, Kun Qian, Zhao Fang, Feng Gu, Baisong Chang, Zhen Cheng   +9 more
wiley   +1 more source

Slow Waves Analysis Pipeline for extracting the Features of the Bi-Modality from the Cerebral Cortex of Anesthetized Mice [PDF]

, 2019
Cortical slow oscillations are an emergent property of the cortical network, a hallmark of low complexity brain states like sleep, and represent a default activity pattern. Here, we present a methodological approach for quantifying the spatial and temporal properties of this emergent activity.
arxiv   +1 more source

Flexible Optoelectronic Hybrid Microfiber Long‐period Grating Multimodal Sensor

Advanced Science, EarlyView.
An entirely new optoelectronic hybrid multimodal optical fiber sensor which can simultaneously monitor biomechanics and glucose is demonstrated. The developed method simultaneously integrates two heterogeneous sensing mechanisms, optical and electrical, into a single sensor in a compact manner. Optical and electrical sensors can work simultaneously but
Zhenru Li, Li‐Peng Sun, Yanzhen Tan, Zhiwei Wang, Xiao Yang, Tiansheng Huang, Jie Li, Yi Zhang, Bai‐Ou Guan   +8 more
wiley   +1 more source

Characterization of the Community Structure of Large-Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction [PDF]

arXiv, 2016
One of the main goals of neuroscience is to understand how an organism's cognitive capacities or physiological states are potentially related to brain activities that involve the interaction of multiple brain structures and cortical areas. A key feature of functional brain networks is that they are modularly structured, and this modular architecture is
arxiv  

Anesthesia in Pediatric Eye Surgery (Review)

Общая реаниматология, 2018
The review dwells on the analysis of anesthetic techniques for pediatric eye surgery, including the use of drugs used and methods of anesthesia. While preparing the paper, Cyberleninka (www.cyberleninka.ru), PubMed, Medline databases were used with the ...
Lyudmila S. Korobova, Vladimir V. Lazarev   +1 more
doaj   +1 more source

IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex

Advanced Science, EarlyView.
This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv, Wenzheng Zou, Lin Li, Shukui Zhang, Jiaqi Liang, Jiali Pu, Jianwei Jiao   +6 more
wiley   +1 more source

The appearance of phagocytic microglia in the postnatal brain of Niemann Pick type C mice is developmentally regulated and underscores shortfalls in fine odor discrimination

Journal of Cellular Physiology, Volume 237, Issue 12, Page 4563-4579, December 2022., 2022
Abstract The loss of NPC1 or NPC2 function results in cholesterol and sphingolipid dyshomeostasis that impairs developmental trajectories, predisposing the postnatal brain to the appearance of pathological signs, including progressive and stereotyped Purkinje cell loss and microgliosis.
Alessandro Rava, Piergiorgio La Rosa, Giampiero Palladino, Jessica Dragotto, Antonio Totaro, Jessica Tiberi, Sonia Canterini, Sergio Oddi, Maria Teresa Fiorenza   +8 more
wiley   +1 more source

Characterization of Large-Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction [PDF]

arXiv, 2016
Several experiments provide evidence that specialized brain regions functionally interact and reveal that the brain processes and integrates information in a specific and structured manner. Networks can be applied to model brain functional activities, providing means to characterize and quantify this structured form of organization.
arxiv