Results 231 to 240 of about 548,111 (319)

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

open access: yesAging Cell, EarlyView.
Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik   +20 more
wiley   +1 more source

Instructional design features in ultrasound‐guided regional anaesthesia simulation‐based training: a systematic review

open access: yesAnaesthesia, Volume 80, Issue 5, Page 572-581, May 2025.
Summary Introduction Ultrasound‐guided regional anaesthesia enhances pain control, patient outcomes and lowers healthcare costs. However, teaching this skill effectively presents challenges with current training methods. Simulation‐based medical education offers advantages over traditional methods.
Pooyan Sekhavati   +8 more
wiley   +1 more source

Genome‐wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank

open access: yesAnaesthesia, Volume 80, Issue 5, Page 499-510, May 2025.
Summary Introduction Chronic pain is one of the most common and severe complications after surgery, affecting quality of life and overall wellbeing of patients. Several risk factors have been identified but the mechanisms of chronic postsurgical pain development remain unclear.
Song Li   +7 more
wiley   +1 more source

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