Results 81 to 90 of about 16,229 (219)

Long‐Term Stable Subdural Recordings Enabled by Fibrosis‐Resistant Hydrogel‐Integrated µECoG Arrays

Advanced Science, EarlyView.
An adhesive hydrogel‐integrated micro‐electrocorticography (aGel‐µECoG) array is developed to ensure stable neural recordings by minimizing neuroinflammation and fibrosis during implantation. The hydrogel serves as a biological and mechanical bridge, enabling bioadhesive, reversible, anti‐fibrotic integration with brain tissue.
Lin Chen, Hao Zhong, Linghao Wang, Liju Xu, Wanying Fan, Yongpeng Zhao, Huiling Zhang, Yang Shen, Kai Wu, Xin Fu, Jingxiang Guo, Ke Li, Dong Qiu, Ting Wu   +13 more
wiley   +1 more source

Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia

Advanced Science, EarlyView.
Multi‐modal optical imaging reveals microvascular pulsatility in the brain cortex of awake and anaesthetized mice. Awake hemodynamics in male mice are found to be remarkably stable until late life, with flow pulsatility being significantly higher than in females, despite similar average perfusion.
Mia Viuf Skøtt, Elizaveta Melnikova, Eugenio Gutiérrez, Vladimir Matchkov, Leif Østergaard, Dmitry D Postnov   +5 more
wiley   +1 more source

Validation of the Safe Application of Tokyo Guideline 2018 (TG18) Severity Grading and Treatment Algorithm in Super‐Elderly Patients Aged 85 and Over With Acute Cholecystitis: A Study in the Japanese Tertiary Care Hospital

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background With population aging and extended healthy life expectancy, the management of acute cholecystitis (AC) in patients aged ≥ 85 years has evolved. However, the Tokyo Guidelines 2018 (TG18) for AC provide no specific risk assessment criteria for this population.
Yuta Kobayashi, Ryo Oikawa, Yumi Shibuya, Masakazu Tatsuno, Atsuya Kamiyama, Tsuyoshi Ozawa, Keiichiro Hara, Shinogu Hatano, Shojiro Hata, Hirokazu Yamaguchi   +9 more
wiley   +1 more source

Riemannian Geometry for the Classification of Brain States with Intracortical Brain Recordings

Advanced Intelligent Systems, EarlyView.
Geometric machine learning is applied to decode brain states from invasive intracortical neural recordings, extending Riemannian methods to the invasive regime where data is scarcer and less stationary. A Minimum Distance to Mean classifier on covariance manifolds uses geodesic distances to outperform convolutional neural networks while reducing ...
Arnau Marin‐Llobet, Sergio Sánchez‐Manso, Arnau Manasanch, Lluc Tresserras, Xinhe Zhang, Yining Hua, Hao Zhao, Melody Torao‐Angosto, Maria V Sanchez‐Vives, Leonardo Dalla Porta   +9 more
wiley   +1 more source

Efficacy of Local Bupivacaine Injection of Postoperative Pain in Endoscopic Sinus Surgery

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Regional anesthesia is effective in alleviating postoperative pain and reducing the requirement for systemic pain medications. However, optimal postoperative pain management in endoscopic sinus surgery (ESS) remains challenging.
Wiracha Leewannapasai, Navarat Tangbumrungtham, Kanokporn Sarsitthithum, Kangsadarn Tanjararak, Boonsam Roongpuvapaht   +4 more
wiley   +1 more source

Identifying Predictive Biomarkers of Response in Patients With Rheumatoid Arthritis Treated With Adalimumab Using Machine Learning Analysis of Whole‐Blood Transcriptomics Data

Arthritis &Rheumatology, EarlyView.
Objective Tumornecrosis factor inhibitors (TNFi) have significantly improved rheumatoid arthritis (RA) management, yet variability in patient response remains a substantial challenge, with approximately 40% of patients discontinuing TNFi due to nonresponse or adverse effects.
Chuan Fu Yap, Nisha Nair, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme Hyrich, Guillermo Barturen, María Riva‐Torrubia, Marta Gut, Ivo Gut, Marta E. Alarcón Riquelme, Anne Barton, Darren Plant   +12 more
wiley   +1 more source

Monocyte‐Derived Macrophages‐Synovial Fibroblasts Crosstalk Unravels Oncostatin Signaling Network as a Driver of Synovitis in Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis (OA) is a debilitating joint disease that is characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet, Olivier Bortolotti, Léa Marineche, Nicole Hannemann, Manon Chambon, Yaël Glasson, Anne‐Sophie Dumé, Julien De Lima, Maud Fournial, Dylan Touchet, Dany Séverac, Felicia Leccia, Christophe Duperray, Henri‐Alexandre Michaud, Farida Djouad, Benoît Le Goff, Frédéric Blanchard, Florence Apparailly, Gabriel Courties   +18 more
wiley   +1 more source

Serum cytokine profiling differentiates underlying diseases in cytokine storm syndrome

Arthritis &Rheumatology, Accepted Article.
Objective Cytokine storm syndrome (CSS), commonly associated with hemophagocytic lymphohistiocytosis (HLH), is a fatal hyperinflammatory syndrome. Differentiating the underlying diseases responsible for CSS is essential for timely therapeutic decisions. This study explored the clinical usefulness of serum cytokine profiling in distinguishing underlying
Shuya Kaneko, Maho Hatano, Asami Shimbo, Futaba Miyaoka, Hitoshi Irabu, Yuko Akutsu, Yuko Hayashi, Mao Mizuta, Yasuo Nakagishi, Keiji Akamine, Naomi Iwata, Kenji Furuno, Takayuki Tanaka, Kazuyuki Ueno, Shuhei Fujita, Koji Yokoyama, Toshinori Minato, Kazushi Izawa, Takahiro Yasumi, Tadashi Matsubayashi, Tadashi Hosoya, Hiroki Nishikawa, Junya Fujimura, Ryoko Asano, Yuko Sugita, Kenichi Watanabe, Anna Kobayashi, Takuya Endo, Katsuhide Eguchi, Ryuta Nishikomori, Ryuhei Yasuoka, Takaki Asano, Miyako Kanno, Kazuya Hamada, Yuji Fujita, Daisuke Hayashi, Shojiro Watanabe, Takeshi Shiba, Shinsuke Yasuda, Masaaki Mori, Hirokazu Kanegane, Masatoshi Takagi, Masaki Shimizu   +42 more
wiley   +1 more source

Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes

Arthritis &Rheumatology, Accepted Article.
Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. Variable copy number (CN) of C4 genes and retroviral HERV‐K element influence its function.
Javier Martínez‐López, Carlos Rangel‐Peláez, Inmaculada Rodriguez‐Martin, Alfredo Guillen‐Del‐Castillo, Carmen P Simeón‐Aznar, José L Callejas, International SSc Group; PRECISESADs Clinical Consortium, Oliver Distler, Susanna M Proudman, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), Nicolas Hunzelmann, Gianluca Moroncini, Jeska K de Vries‐Bouwstra, Ariane L Herrick, Yannick Allanore, Marta E. Alarcon‐Riquelme, Lorenzo Beretta, Shervin Assassi, Christopher P Denton, Maureen D Mayes, Javier Martin, Marialbert Acosta‐Herrera, Martin Kerick   +23 more
wiley   +1 more source

A global overview of anatomical science education and its present and future role in biomedical curricula

Anatomical Sciences Education, EarlyView.
How the anatomical sciences are taught worldwide is constantly changing. Common themes are a reduction of teaching time and the inclusion of e‐learning and new pedagogical approaches. Although there is a common direction of change, where different global regions place along that trajectory often correlates with their economic status.
Michael Hortsch, Virginia Claudia Carneiro Girão‐Carmona, Ana Caroline Rocha de Melo Leite, Ilias P. Nikas, Margaret K. Gatumu, Nii Koney‐Kwaku Koney, Benjamin Arko‐Boham, Doris George Yohannan, Aswathy Maria Oommen, Yan Li, Jian Yang, Alexandra F. Trollope, Amanda J. Meyer, Sonya E. Van Nuland   +13 more
wiley   +1 more source