Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang+13 more
wiley +1 more source
Anesthesia in endovascular abdominal aortic aneurysm (AAA) repair [PDF]
Introduction: endovascular AAA repair can be done using different anesthetic techniques, such as general anesthesia, regional block, and local anesthesia associated with sedation.
Kora, M., Potseluev, V.
core
LIN28B Promotes Cancer Cell Dissemination and Angiogenesis
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo+8 more
wiley +1 more source
Mechanisms of Volatile Anesthetic-Induced Myocardial Protection [PDF]
Volatile anesthetics protect myocardium against reversible and irreversible ischemic injury. Experimental evidence from several in vitro and in vivo animal models demonstrates that volatile agents enhance the recovery of stunned myocardium and reduce the
Gu, Weidong+6 more
core +1 more source
Adaptive computation of multiscale entropy and its application in EEG signals for monitoring depth of anesthesia during surgery [PDF]
Entropy as an estimate of complexity of the electroencephalogram is an effective parameter for monitoring the depth of anesthesia (DOA) during surgery.
Cheng-Wei Lu+10 more
core +2 more sources
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu+12 more
wiley +1 more source
Genetic study in patients operated dentally and anesthetized with articaine-epinephrine [PDF]
Aims: In this study we wanted to figure out if there was a correlation between OPRM1 N40D, TRPV1 I316M, TRPV1 I585V, NOS3 −786T>C and IL6 −174C>G polymorphisms and the response to locally applied articaine-epinephrine anesthetic.
Cieza-Borrella, C+5 more
core +2 more sources
Spheroid Cell Aggregation Enhanced by Enzyme‐Free Ultrasound‐Detached Cells
This study demonstrates that ultrasound‐based, enzyme‐free cell detachment accelerates spheroid formation by preserving surface proteins, reducing variability, and enhancing cell aggregation. Comparable engraftment and improved spatial organization in co‐cultured spheroids are observed.
Julien van Delft+7 more
wiley +1 more source
Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez+3 more
wiley +1 more source
Outcomes of intra-articular corticosteroid injections for adolescents with hip pain. [PDF]
Intra-articular injection of corticosteroid and anesthetic (CSI) is a useful diagnostic tool for hip pain secondary to labral tears or femoroacetabular impingement (FAI).
Pandya, Nirav K+2 more
core +2 more sources