Results 351 to 360 of about 302,831 (404)
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INHALATION ANESTHETICS AND ANESTHETIC UPTAKE

Veterinary Surgery, 1975
With the advent of new inhalant anesthetic agents and specialized equipment for their administration, inhalation anesthesia has become the method of choice of many small and large animal practitioners.
openaire   +2 more sources

Additives to local anesthetics for peripheral nerve blocks: Evidence, limitations, and recommendations.

American Journal of Health-System Pharmacy, 2014
PURPOSE The therapeutic rationale, clinical effectiveness, and potential adverse effects of medications used in combination with local anesthetics for peripheral nerve block therapy are reviewed.
N. Bailard, Jaime Ortiz, R. A. Flores
semanticscholar   +1 more source

Neurotoxicity of Anesthetics

Anesthesiology, 1979
Anesthetic toxicity can be strictly defined as a potentially harmful action or effect that is not part of the expected anesthetic or pharmacologic action of the agent. Such a definition would exclude the undesirable effects of an overdose of an anesthetic agent (wherein the expected pharmacologic effects are simply exaggerated) or a recognized expected
John D. Michenfelder   +1 more
openaire   +3 more sources

The Anesthetic Efficacy of Midazolam in the Enflurane-anesthetized Dog

Anesthesiology, 1987
This study determined the anesthetic efficacy of midazolam (MID) in terms of its ability to reduce enflurane MAC (EMAC). Control EMAC was determined by the tail-clamp method in 15 mongrel dogs. Each animal then received at least three incremental infusion rates of MID from among the following: 0.48, 2.4, 9.6, 19.2, 28.8, 48, or 151.2 micrograms.kg-1 ...
Ian M. Schwieger   +2 more
openaire   +3 more sources

Molecular determinants of state-dependent block of Na+ channels by local anesthetics.

Science, 1994
Sodium ion (Na+) channels, which initiate the action potential in electrically excitable cells, are the molecular targets of local anesthetic drugs. Site-directed mutations in transmembrane segment S6 of domain IV of the Na+ channel alpha subunit from ...
D. Ragsdale   +3 more
semanticscholar   +1 more source

Mechanisms of actions of inhaled anesthetics.

New England Journal of Medicine, 2003
“Suffering so great as I underwent cannot be expressed in words . . . but the blank whirlwind of emotion, the horror of great darkness, and the sense of desertion by God and man, which swept through my mind, and overwhelmed my heart, I can never forget ...
J. Campagna, K. Miller, S. Forman
semanticscholar   +1 more source

The effect of anesthetic charge on anesthetic-phospholipid interactions

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1981
Cationic and uncharged forms of a tertiary amine local anesthetic are reported to have different properties and potencies as nerve blocking agents. However, the relative capacities of each form of the local anesthetic to perturb the properties of different model membrane systems is unknown.
Philip S. Low, Stephen R. Davio
openaire   +3 more sources

THE EFFECT OF ANESTHETICS ON HEPATIC FUNCTION

, 1928
Experimental studies on liver function are often carried out under anesthesia, although it is being increasingly recognized that anesthetics modify physiologic processes; the pharmacologist has also shown that they alter the response of the body to many ...
S. Rosenthal, W. Bourne
semanticscholar   +1 more source

Exaggerated Anesthetic Requirements in the Preferentially Anesthetized Brain

Anesthesiology, 1993
The brain is assumed to be the site of anesthetic action, but anesthetics have effects elsewhere, such as the spinal cord. A preferentially anesthetized goat brain model was used to determine the importance of anesthetic action in the brain.Six goats were anesthetized with isoflurane; after tracheal intubation and insertion of a femoral arterial ...
Kevin Schwartz, Joseph F. Antognini
openaire   +3 more sources

Intravenous anesthetics

Current Opinion in Anaesthesiology, 2001
Intravenous anesthetics continue to be a mainstay in the modern anesthesiologist's armamentarium. In this review the authors will discuss new advancements in the use of propofol, as well as a greater understanding as to its mechanism of action. Further, we will discuss the use of target controlled infusion systems, touch upon the possible benefits of ...
J, Petrie, P, Glass
openaire   +2 more sources

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