Results 211 to 220 of about 50,865 (308)

Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

Cell Proliferation, EarlyView.
ECH protects senescent oocytes by stabilising the cytoskeleton, restoring mitochondrial function, reducing oxidative stress and maintaining cellular homeostasis, primarily through the GJA1/SIRT1 signalling pathway. ABSTRACT As maternal age increases, the decline in oocyte quality emerges as a critical factor contributing to reduced reproductive ...
Liuqing Yang, Xinle Lai, Fangxuan Lin, Nan Shi, Xinya Xu, Heng Wang, Xiaotian Li, Dan Shen, Haimo Qian, Xin Jin, Jiayi Chen, Zhongwei Huang, Xing Duan, Qin Zhang   +13 more
wiley   +1 more source

The value of increasing sequencing depth for noninvasive prenatal screening for whole chromosomal aneuploidy. [PDF]

Sci Rep
Wang D, Guo F, Hou Y, Peng H, Hu T, Yang J.   +5 more
europepmc   +1 more source

New insights in cellular senescence: The pituitary model

Journal of Neuroendocrinology, EarlyView.
Senescence is a pivotal process in pituitary tumorigenesis. Recent advances have elucidated the complex mechanisms by which key factors, including IL‐6, establish and maintain senescence in these tumors. Given the critical role of senescence and the development of novel techniques to detect senescent cells, the identification of biomarkers and the ...
Florencia Herbstein, Josefina Rosmino, Mirtha Adriana Guitelman, Joaquina Cagliero, David Gonilski‐Pacin, Nicolas Ciancio Del Giudice, Manuel Fiz, Mariana Fuertes, Eduardo Arzt   +8 more
wiley   +1 more source

The evolution of cell-free fetal DNA testing: expanded non-invasive prenatal testing and its effect on target populations. [PDF]

Front Med (Lausanne)
Yang S, He Y, Lv J, Li R, Fu X.
europepmc   +1 more source

Pituitary Tumor Transforming Gene Causes Aneuploidy and p53-dependent and p53-independent Apoptosis [PDF]

, 2000
Run Yu, Anthony P. Heaney, Wenge Lu, Jiandong Chen, Шломо Мелмед   +4 more
openalex   +1 more source

Whole‐Genome Sequencing and Phenotyping Reveal Specific Adaptations of Lachancea thermotolerans to the Winemaking Environment

Molecular Ecology, EarlyView.
ABSTRACT Adaptation to the environment plays an essential role in yeast evolution as a consequence of selective pressures. Lachancea thermotolerans, a yeast related to fermentation and one of the current trends in wine technology research, has undergone an anthropisation process, leading to a notable genomic and phenomic differentiation.
Javier Vicente, Anne Friedrich, Joseph Schacherer, Kelle Freel, Domingo Marquina, Antonio Santos   +5 more
wiley   +1 more source

Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer. [PDF]

EMBO J
Bökenkamp JE, Keuper K, Redel S, Barthel K, Johnson L, Becker A, Wieland A, Räschle M, Storchová Z.   +8 more
europepmc   +1 more source

Chromosomal Instability Syndrome of Total Premature Chromatid Separation with Mosaic Variegated Aneuploidy Is Defective in Mitotic-Spindle Checkpoint [PDF]

, 2000
Shinya Matsuura, Emi Ito, Hiroshi Tauchi, Kenshi Komatsu, Tatsuro Ikeuchi, Tadashi Kajii   +5 more
openalex   +1 more source

Evolution of Hybrid Inviability Associated With Chromosome Fusions

Molecular Ecology, EarlyView.
ABSTRACT Chromosomal rearrangements, such as inversions, have received considerable attention in the speciation literature due to their hampering effects on recombination. Less is known about how other rearrangements, such as chromosome fissions and fusions, can affect the evolution of reproductive isolation. Here, we use crosses between populations of
Jesper Boman, Karin Näsvall, Roger Vila, Christer Wiklund, Niclas Backström   +4 more
wiley   +1 more source

A perspective review on the systematic implementation of ctDNA in phase I clinical trial drug development. [PDF]

J Exp Clin Cancer Res
Guigal-Stephan N, Lockhart B, Moser T, Heitzer E.   +3 more
europepmc   +1 more source