Results 251 to 260 of about 50,865 (308)

LINC01235 Promotes Clonal Evolution through DNA Replication Licensing‐Induced Chromosomal Instability in Breast Cancer

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study elucidates the mechanism underlying LINC01235 promotes clonal evolution and selection under treatment pressure by facilitating DNA replication licensing and CIN, leading to increased therapeutic resistance in HER2+ breast cancer. Targeting LINC01235‐related pathways with ATR inhibitors may be a viable strategy for clinical application ...
Qi Zhang, Xuliren Wang, Zhibo Shao, Yi Zhang, Liyi Zhang, Ming Chen, Xujie Zhou, Han Zhu, Yue Zhou, Xinya Lu, Pei Li, Weiru Chi, Lun Li, Zhi‐Ming Shao, Shenglin Huang, Jingyan Xue, Yayun Chi, Jiong Wu, Bingqiu Xiu   +18 more
wiley   +1 more source

Ploidy status analysis in small cell lung cancer cells and its use in cytopathological diagnosis. [PDF]

Int J Clin Exp Pathol
He S, Zhang J, Wan T, Deng H, Li D.
europepmc   +1 more source

Evaluation of aneuploidy and DNA damage in human spermatozoa: applications in field studies

, 2000
Sally D. Perreault, Jiřı́ Rubeš, W. A. Robbins, D.P. Evenson, S G Selevan   +4 more
openalex   +1 more source

Breaking the Bone Marrow Barrier: Peripheral Blood as a Gateway to Measurable Residual Disease Detection in Acute Myelogenous Leukemia

American Journal of Hematology, Volume 100, Issue 4, Page 638-651, April 2025.
ABSTRACT Acute myeloid leukemia (AML) is a genetically heterogeneous disease with high rates of relapse after initial treatment. Identifying measurable residual disease (MRD) following initial therapy is essential to assess response, predict patient outcomes, and identify those in need of additional intervention.
John T. Butler, William M. Yashar, Ronan Swords   +2 more
wiley   +1 more source

The hidden costs of aneuploidy: New insights from yeast. [PDF]

Cell Genom
Wang Y, Fu X, Shen Y.
europepmc   +1 more source

Delaying Motherhood—An Increasingly Common but Risky Trend in High‐Income Countries

American Journal of Human Biology, Volume 37, Issue 4, April 2025.
ABSTRACT Objectives Maternal age at first birth is increasing in most high‐income countries. The associations between advanced maternal age and perinatal complications, as well as newborn parameters, were analyzed using a dataset of 6831 singleton births among first‐time mothers taking place in Vienna, Austria, between 2010 and 2019.
Magdalena Kraus, Beda Hartmann, Sylvia Kirchengast   +2 more
wiley   +1 more source

Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos. [PDF]

Elife
Regin M, Lei Y, Couvreu De Deckersberg E, Janssens C, Huyghebaert A, Guns Y, Verdyck P, Verheyen G, Van de Velde H, Sermon K, Spits C.   +10 more
europepmc   +1 more source

Circulating Tumour DNA in Patients With EGFR‐Mutated Non‐Small‐Cell Lung Cancer and Early Disease Progression After First‐Line Osimertinib Treatment: The ELUCIDATOR Multicentre Prospective Observational Study

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Osimertinib is the standard therapy for patients with chemotherapy‐naive advanced non‐small‐cell lung cancer (NSCLC) harbouring sensitising epidermal growth factor receptor (EGFR) mutations. However, some patients treated with osimertinib experience progressive disease (PD).
Akihiro Tamiya, Yasuyuki Mizumori, Mitsuo Osuga, Shun‐ichi Isa, Yoshihiko Taniguchi, Keiichi Nakamura, Daijiro Harada, Tsutomu Shinohara, Hidetoshi Yanai, Katsumi Nakatomi, Masahide Oki, Masahide Mori, Tomohito Kuwako, Koji Yamazaki, Atsuhisa Tamura, Masahiko Ando, Yasuhiro Koh   +16 more
wiley   +1 more source

A myeloid IFN gamma response gene signature correlates with cancer prognosis

Clinical and Translational Medicine, Volume 15, Issue 4, April 2025.
IFGRNS score is a novel prognostic biomarker upregulated in myeloid lineage cells. IFGRNS score correlates with survival outcomes across multiple cancer types. IFGRNS score is associated with tumour pathology and immune microenvironment. IFGRNS score predicts immunotherapy response, with potential for clinical application. Abstract Background The IFN‐γ
Yuchao Zhang, Asma Khanniche, Yizhe Li, Zhenchuan Wu, Hailong Wang, Hongyu Zhang, Xiaoxue Li, Landian Hu, Xiangyin Kong   +8 more
wiley   +1 more source

Uptake rates for non-invasive prenatal screening for single-gene disorders associated with advanced paternal age. [PDF]

J Genet Couns
Katz K, Brandt JS, Heiman G, Simone L, Khan S, Shingala P, Ashkinadze E.   +6 more
europepmc   +1 more source