Results 261 to 270 of about 97,243 (292)

Long‐read sequencing reveals genomic and epigenomic variation in the dark genome of human Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Faulty DNA repair and epigenetic regulation contribute to neurodegeneration in Alzheimer's disease. Long‐read sequencing enables analysis of “dark regions” that are difficult to study via traditional sequencing methodologies.
Paulino Ramirez, Wenyan Sun, Shiva Kazempour Dehkordi, Habil Zare, Giovanni Pascarella, Piero Carninci, Bernard Fongang, Kevin F. Bieniek, Bess Frost   +8 more
wiley   +1 more source

Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation. [PDF]

Genes Dev
Magesh RY, Kaur AN, Keller FN, Frederick A, Tseyang T, Haley JA, Rivera-Nieves AM, Liang AC, Guertin DA, Spinelli JB, Elledge SJ, Watson EV.   +11 more
europepmc   +1 more source

Are aneuploidy and chromosome breakage caused by a CINgle mechanism?

, 2010
Carlos Martı́nez-A, Karel H. M. van Wely   +1 more
openalex   +2 more sources

BUB1B Promotes Ovarian Cancer Cell Proliferation and Metastasis by Activating the Wnt/β‐Catenin Pathway

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Background BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) has been found to participate in cancer progression. Nevertheless, the function and mechanism of BUB1B in ovarian cancer (OC) remain unknown. Method Based on datasets GSE14407, GSE18520, and the TCGA combined GTEx database, the differently expressed genes (DEGs) between OC ...
Jing Wang, Xiaoling Su, Nan Lin, Tao Su
wiley   +1 more source

Co-mutation of PCLO and SYNE1 defines an immune-activated endometrial cancer subtype with favorable prognosis. [PDF]

J Obstet Gynaecol Res
Wu C, Han D, Li X, Wang D, Jin H.
europepmc   +1 more source

Clinical Impact of Immunoglobulin Heavy Chain Clonality in Pediatric B‐Cell Precursor Acute Lymphoblastic Leukemia

Cancer Medicine, Volume 14, Issue 21, November 2025.
IGH clonality analysis by RNA sequencing revealed distinct prognostic groups in pediatric BCP‐ALL. Our results demonstrate the value of sequencing‐based IGH profiling to enhance relapse risk assessment and guide precision monitoring strategies. ABSTRACT Introduction Recent advancements in risk stratification have greatly improved outcomes in pediatric ...
Yuta Katai, Tatsuya Kamitori, Satoshi Saida, Yoshinori Uchihara, Ryo Akazawa, Kiyotaka Isobe, Takashi Mikami, Hirohito Kubota, Itaru Kato, Katsutsugu Umeda, Hiroo Ueno, Junko Takita   +11 more
wiley   +1 more source

High-precision intraoperative diagnosis of gliomas: integrating imaging and intraoperative flow cytometry with machine learning. [PDF]

Front Neurol
Koriyama S, Matsui Y, Shioyama T, Onodera M, Tamura M, Kobayashi T, Ro B, Masui K, Komori T, Muragaki Y, Kawamata T.   +10 more
europepmc   +1 more source

Clinical application of single‐cell RNA sequencing in disease and therapy

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
This review provides a comprehensive overview of the application of scRNA‐seq in revisiting the somatic cell evolutions in human diseases, as well as in biomarker discovery and drug development. Abstract Background The emergence of single‐cell RNA sequencing (scRNA‐seq) technology has revolutionized our capacity to study cell functions in complex ...
Aisha Shigna Nadukkandy, Sowmiya Kalaiselvan, Lin Lin, Yonglun Luo   +3 more
wiley   +1 more source

Clinical experience of genome-wide non-invasive prenatal testing as a first-tier screening test in a cohort of 59,771 pregnancies. [PDF]

PLoS One
Zhen J, Zhang L, Wang H, Chen X, Wang W, Li L, Zhang Q.   +6 more
europepmc   +1 more source

Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand

The Journal of Pathology, Volume 267, Issue 3, Page 261-274, November 2025.
Abstract Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to the endemic liver fluke Opisthorchis viverrini.
Raksawan Deenonpoe, Molly A Guscott, Sasithorn Watcharadetwittaya, Isabel L McNeill, Daniela Moralli, Nadeem Shaikh, Sarah E McClelland   +6 more
wiley   +1 more source