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Aneuploidy in mammalian oocytes and the impact of maternal ageing
Nature reviews. Molecular cell biology, 2022Chloe Charalambous+2 more
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Antenatal screening for aneuploidy
Current Opinion in Obstetrics and Gynaecology, 1998There are several methods of antenatal screening for aneuploidy. Most are aimed at the identification of women at increased risk of Down syndrome, the most common abnormal karyotype conferring a significant risk of serious long-term morbidity. Traditional maternal-age-based screening has largely been replaced by programmes based on biochemical markers ...
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Aneuploidy and tumorigenesis in Drosophila
Seminars in Cell & Developmental Biology, 2014Aneuploidy, described as an abnormal number of whole chromosomes or parts of them, has been observed in the majority of sporadic carcinomas, the most common type of cancer occurring in humans and derived from putative epithelial cells. However, the causal relationship between aneuploidy and tumorigenesis remains highly debated.
Milán, Marco+3 more
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Effects of aneuploidy on cell behaviour and function
Nature reviews. Molecular cell biology, 2022Rong Li, Jin Zhu
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Aneuploidy as a promoter and suppressor of malignant growth
Nature Reviews. Cancer, 2021A. Vasudevan+5 more
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Tumor aneuploidy predicts survival following immunotherapy across multiple cancers
Nature Genetics, 2022Liam F. Spurr+2 more
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Science, 2007
An extra chromosome slows yeast cell proliferation, suggesting that aneuploid human cells must overcome this effect during carcinogenesis.
David Pellman, Prasad V. Jallepalli
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An extra chromosome slows yeast cell proliferation, suggesting that aneuploid human cells must overcome this effect during carcinogenesis.
David Pellman, Prasad V. Jallepalli
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The Origin of Aneuploidy in Humans [PDF]
Aneuploidy is the most common class of chromosome abnormality in humans and is considered by some to be the most important genetic hazard facing man (2). No less than 0.3% of all newborns are aneuploid (12), most with significant physical, intellectual, and behavioral abnormalities. Furthermore, these individuals are the least affected of all aneuploid
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2018
Sex chromosome aneuploidies comprise a relatively common group of chromosome disorders characterized by the loss or gain of one or more sex chromosomes. We discuss five of the better-known sex aneuploidies: Turner syndrome (XO), Klinefelter syndrome (XXY), trisomy X (XXX), XYY, and XXYY.
David Skuse+2 more
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Sex chromosome aneuploidies comprise a relatively common group of chromosome disorders characterized by the loss or gain of one or more sex chromosomes. We discuss five of the better-known sex aneuploidies: Turner syndrome (XO), Klinefelter syndrome (XXY), trisomy X (XXX), XYY, and XXYY.
David Skuse+2 more
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Context is everything: aneuploidy in cancer
Nature reviews genetics, 2019U. Ben-David, A. Amon
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