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The diverse consequences of aneuploidy
Nature Cell Biology, 2019Aneuploidy, or imbalanced chromosome number, has profound effects on eukaryotic cells. In humans, aneuploidy is associated with various pathologies, including cancer, which suggests that it mediates a proliferative advantage under these conditions.
Narendra Kumar Chunduri +1 more
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Aneuploidy in Human Spermatozoa [PDF]
Cytogenetic and Genome Research, 2011 We reviewed the frequency and distribution of disomy in spermatozoa obtained by multicolor-FISH analysis on decondensed sperm nuclei in (a) healthy men, (b) fathers of aneuploid offspring of paternal origin and (c) individuals with Klinefelter syndrome and XYY males. In series of healthy men, disomy per autosome is approximately 0.1% but may range from
A Estop +2 more
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Comparisons of tests for aneuploidy
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1987The fundamental problems that face us in the development of suitable assay systems for the detection of potentially aneugenic (aneuploidy-inducing) chemicals include: (a) the diversity of cellular targets and mechanisms where perturbations of structure and function may give rise to changes in chromosome number, and (b) the phylogenetic differences that
James M. Parry, Elizabeth M. Parry
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American Journal of Botany, 1972
Analyses of ploidy levels in progenies from 2x x 2x, 2x x 4x, 4x x 2x, 4x X 4x, and 4x x OP crosses during embryogenesis and seed germination indicate that the progenies include an array of aneuploids. The occurrence of some of the aneuploids was previously unreported.
Asim Esen, Robert K. Soost
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Analyses of ploidy levels in progenies from 2x x 2x, 2x x 4x, 4x x 2x, 4x X 4x, and 4x x OP crosses during embryogenesis and seed germination indicate that the progenies include an array of aneuploids. The occurrence of some of the aneuploids was previously unreported.
Asim Esen, Robert K. Soost
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Predisposition to Aneuploidy in the Oocyte
Cytogenetic and Genome Research, 2011While the incidence of predisposition to aneuploidy in the oocyte increases with age, there is also evidence of increased incidence in young women with recurrent miscarriage, recurrent aneuploidy, or recurrent implantation failure after in vitro fertilization. There is evidence from mouse models and from observations in humans that follicle-stimulating
D. Molina-Gomes +3 more
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Aneuploidy in the driving seat
Nature Reviews Genetics, 2021Attempts to understand the role of aneuploidy in tumorigenesis have been hampered by conflicting results. Now, two new mouse models described in Genes and Development provide evidence that chromosome instability-induced aneuploidy drives T cell lymphomagenesis.
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Aneuploidy and tumorigenesis in Drosophila
Seminars in Cell & Developmental Biology, 2014Aneuploidy, described as an abnormal number of whole chromosomes or parts of them, has been observed in the majority of sporadic carcinomas, the most common type of cancer occurring in humans and derived from putative epithelial cells. However, the causal relationship between aneuploidy and tumorigenesis remains highly debated.
Milán, Marco +3 more
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Antenatal screening for aneuploidy
Current Opinion in Obstetrics and Gynaecology, 1998There are several methods of antenatal screening for aneuploidy. Most are aimed at the identification of women at increased risk of Down syndrome, the most common abnormal karyotype conferring a significant risk of serious long-term morbidity. Traditional maternal-age-based screening has largely been replaced by programmes based on biochemical markers ...
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Science, 2007
An extra chromosome slows yeast cell proliferation, suggesting that aneuploid human cells must overcome this effect during carcinogenesis.
David Pellman, Prasad V. Jallepalli
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An extra chromosome slows yeast cell proliferation, suggesting that aneuploid human cells must overcome this effect during carcinogenesis.
David Pellman, Prasad V. Jallepalli
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The Origin of Aneuploidy in Humans [PDF]
, 1985 Aneuploidy is the most common class of chromosome abnormality in humans and is considered by some to be the most important genetic hazard facing man (2). No less than 0.3% of all newborns are aneuploid (12), most with significant physical, intellectual, and behavioral abnormalities. Furthermore, these individuals are the least affected of all aneuploid
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