Results 311 to 320 of about 95,739 (341)
Some of the next articles are maybe not open access.
Journal of Intellectual Disability Research, 1980
On one hundred consecutive clinically referred patients, a total of 3,175 cells was fully analysed. The parameters of culture and analysis were the same for all patients, and a breakdown of cells showed 258 cells (8.1 per cent) with hypomodal counts and sixty-two cells (1.9 per cent) with hypermodal counts.
Gae Elliott, Arabella Smith
openaire +3 more sources
On one hundred consecutive clinically referred patients, a total of 3,175 cells was fully analysed. The parameters of culture and analysis were the same for all patients, and a breakdown of cells showed 258 cells (8.1 per cent) with hypomodal counts and sixty-two cells (1.9 per cent) with hypermodal counts.
Gae Elliott, Arabella Smith
openaire +3 more sources
Current Opinion in Obstetrics and Gynaecology, 1999
Over the past 15 years, biochemical screening for chromosomal abnormalities, particularly Down's syndrome, has advanced from being extremely naive, to now somewhat more sophisticated. Sensitivities have gone from 20% to 60-70%. Considerable work is still required to not only increase the sensitivity, but also the specificity to keep health care costs ...
Anthony Johnson +2 more
openaire +3 more sources
Over the past 15 years, biochemical screening for chromosomal abnormalities, particularly Down's syndrome, has advanced from being extremely naive, to now somewhat more sophisticated. Sensitivities have gone from 20% to 60-70%. Considerable work is still required to not only increase the sensitivity, but also the specificity to keep health care costs ...
Anthony Johnson +2 more
openaire +3 more sources
Journal of Cellular Biochemistry, 2007
AbstractThe cell's euploid status is influenced by, amongst other mechanisms, an intact spindle assembly checkpoint (SAC), an accurate centrosome cycle, and proper cytokinesis. Studies in mammalian cells suggest that dysregulated SAC function, centrosome cycle, and cytokinesis can all contribute significantly to aneuploidy.
Kuan-Teh Jeang, Ya-Hui Chi
openaire +3 more sources
AbstractThe cell's euploid status is influenced by, amongst other mechanisms, an intact spindle assembly checkpoint (SAC), an accurate centrosome cycle, and proper cytokinesis. Studies in mammalian cells suggest that dysregulated SAC function, centrosome cycle, and cytokinesis can all contribute significantly to aneuploidy.
Kuan-Teh Jeang, Ya-Hui Chi
openaire +3 more sources
Reviews in Medical Virology, 2019
SummarySeven oncogenic viruses are known for tumorigenesis and contribute to 12% of all human cancers. The oncogenic factors, the target tissue, and pathology of cancer vary among these viruses with several mechanisms proposed for the initiation and development of cancer. Aneuploidy in cells is associated with anomalies in chromosome number that can be
Fateme Taheri +2 more
openaire +3 more sources
SummarySeven oncogenic viruses are known for tumorigenesis and contribute to 12% of all human cancers. The oncogenic factors, the target tissue, and pathology of cancer vary among these viruses with several mechanisms proposed for the initiation and development of cancer. Aneuploidy in cells is associated with anomalies in chromosome number that can be
Fateme Taheri +2 more
openaire +3 more sources
Nature, 2004
In contrast to normal cells, aneuploidy--alterations in the number of chromosomes--is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells.
Harith Rajagopalan, Christoph Lengauer
openaire +3 more sources
In contrast to normal cells, aneuploidy--alterations in the number of chromosomes--is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells.
Harith Rajagopalan, Christoph Lengauer
openaire +3 more sources
Screening for aneuploidy in twins
American Journal of Obstetrics & Gynecology MFM, 2022All pregnant women should be offered screening for aneuploidy. Twin pregnancies present unique challenges in aneuploidy screening. This review describes available aneuploidy screening options and their benefits and limitations in twin pregnancy, along with describing special circumstances, such as vanishing twins and diagnostic testing in twin ...
Maeve K. Hopkins, Lorraine Dugoff
openaire +3 more sources
Cytokinesis, ploidy and aneuploidy
The Journal of Pathology, 2011AbstractCytokinesis is the last step of cell division that physically separates the daughter cells. As such, it ensures the proper inheritance of both nuclear and cytoplasmic contents. Accomplishment of cytokinesis in eukaryotes is dictated by several key events: establishment of the division plane, furrow ingression through contraction of an ...
Benjamin Lacroix, Amy Shaub Maddox
openaire +2 more sources
Pleural Effusion in Aneuploidy
American Journal of Perinatology, 1991Three consecutive cases of isolated pleural effusion in aneuploid fetuses are reported. The presence of pleural effusion in trisomy 13 had not been described in the literature previously. Early development of pleural effusion is usually associated with fetal hydrops and carries a poor prognosis.
Boris M. Petrikovsky +3 more
openaire +3 more sources
Current Opinion in Oncology, 2000
Numeric aberrations in chromosomes, referred to as aneuploidy, is commonly observed in human cancer. Whether aneuploidy is a cause or consequence of cancer has long been debated. Three lines of evidence now make a compelling case for aneuploidy being a discrete chromosome mutation event that contributes to malignant transformation and progression ...
openaire +3 more sources
Numeric aberrations in chromosomes, referred to as aneuploidy, is commonly observed in human cancer. Whether aneuploidy is a cause or consequence of cancer has long been debated. Three lines of evidence now make a compelling case for aneuploidy being a discrete chromosome mutation event that contributes to malignant transformation and progression ...
openaire +3 more sources