Results 111 to 120 of about 37,027 (266)

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Thoracic aortic aneurysm [PDF]

Annals of Cardiothoracic Surgery, 2016
Christopher, Harris, Beth, Croce, Christopher, Cao   +2 more
openaire   +2 more sources

A Descriptive Evaluation of Evidence‐Based Rounds in Critical Care Using Mixed Data Types

Journal of Advanced Nursing, EarlyView.
ABSTRACT Objectives To pilot and evaluate the implementation of a structured Evidence‐Based Rounds (EBR) education model in critical care. Design A mixed data type design was used to evaluate Evidence‐Based Rounds in a critical care setting. Structured observational data were captured and open‐ended survey responses were submitted by attendees. Content
P. Yerbury, S. Sutherland, T. Venes, A. Nair, J. Ede   +4 more
wiley   +1 more source

Catheter Ablation: Evolution and Efficiencies

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT The present review includes a discussion the goals and pitfalls of efficiency in the medical profession, a historical perspective on the evolution of catheter ablation in the field of electrophysiology (EP), and the data regarding the relationship between efficiency and outcomes in the EP lab. Focus on efficacy is critical to maximize resource
Aravind G. Kalluri, Bradley P. Knight
wiley   +1 more source

Association of glucagon‐like peptide‐1 receptor agonist use with clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
This TriNetX (US, 2016–2023) study compared clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes treated with GLP‐1 receptor agonists vs DPP4 inhibitors. ABSTRACT Objectives To evaluate whether glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are associated with improved survival and renal outcomes in patients with ...
Yu‐Ting Yu, Ying Chun Lee, Yu‐Wei Fang, Wen‐Hui Hsieh, Ming‐Hsien Tsai   +4 more
wiley   +1 more source

Association Between Perioperative Sleep Disorders and Post‐Operative Delirium in Cardiac Surgeries: A Systematic Review and Meta‐Analysis

Journal of Sleep Research, EarlyView.
Overview of studies included in the systematic review investigating the association between perioperative sleep disorders (PSD) and postoperative delirium (POD) in patients undergoing cardiac surgery. ABSTRACT Post‐operative delirium (POD) is an acute deterioration in cognitive function and highly prevalent after cardiac surgery (CS; up to 55 ...
Hesam Varpaei, Pallav Deka, Lorraine B. Robbins, Kousha Farhadi, Mathew Reeves, Fabrice Mowbray, Stuart F. Quan   +6 more
wiley   +1 more source

The Effect of 6 Months of Dietary Counselling on Sleep Outcomes Among Patients With Cardiovascular Diseases: A Randomised Controlled Trial

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep problems are highly prevalent among patients with cardiovascular diseases (CVD). We examined the effect of dietary counselling on sleep outcomes among patients with CVD. We performed secondary analyses within a previously conducted six‐month randomised controlled trial among patients with CVD.
Auke J. C. F. Verkaar, Iris van Damme, Eva R. van Veldhuisen, H. Myrthe Boss, Johanna M. Geleijnse, Renate M. Winkels   +5 more
wiley   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source