TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Abstract In the classroom, metabolism is often approached and received as a mundane exercise in memorization. Teaching metabolism also faces the challenge of negative perceptions that can impede learning. We sought to improve the learning experience in an undergraduate lecture course on microbial metabolism by implementing an illustrated story that ...
James B. McKinlay, Katherine Kearns
wiley +1 more source
On the importance of including both sexes in animal studies – insights from home‐cage monitoring
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater +12 more
wiley +1 more source
Effect of Driving Anger level to anger Expression
Makoto NAKANSHI, Tetuya JIBU
openaire +1 more source
Animal empathy reconsidered: a multidimensional profile account
ABSTRACT Empathy is the glue that holds societies together and yet several fundamental questions about empathy persist. What is empathy (the definitional question)? Is it uniquely human and, if not, which nonhuman animals possess empathy (the distribution question)? Which type or quality of empathy is realized in different species (the quality question)
Albert Newen +5 more
wiley +1 more source
Non-Suicidal Self-Injury Among Italian Adolescents: The Role of Parental Rejection, Self-Concept, Anger Expression, and Body Investment. [PDF]
Cipriano A, Cella S, Cotrufo P.
europepmc +1 more source
The Degradation of Access‐Based Business Models: Customer Misbehavior and Shared Mobility
ABSTRACT Access‐based services are considered one of the strategies to embed sustainability in business models. Yet, because the evolution of these business models has been overlooked, we do not know whether their promise to create triple value is sustained.
Andres Camacho, Carmen Valor
wiley +1 more source
Dimensions of Leader Anger Expression Unveiled: How Anger Intensity and Gender of Leader and Observer Affect Perceptions of Leadership Effectiveness and Status Conferral. [PDF]
Yun D, Jung H, Ashihara K.
europepmc +1 more source
Anger, Anger Expressions and Strategies Adopted for Anger Management
Meha Bhushan, Harpreet Kaur
openaire +1 more source
Default Effect in ESG Investment: When a Recommendation Goes a Long Way
ABSTRACT Individual investors display a positive attitude toward ESG investments but typically fail to act upon it. We report results from a preregistered online experiment testing a default option on 1050 US investors examining the mechanisms driving the effectiveness of default options in promoting ESG investments.
Sai Sravanthi Ramadugula +2 more
wiley +1 more source

