Results 81 to 90 of about 396,597 (302)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Aggression and Risk Behaviors in a Group of Adolescents with High-Functioning Autism

Children
Background/Objectives: Aggression in adolescents with autism, particularly those with high-functioning autism (HFA), presents a unique clinical profile.
Mihaela Moise, Lucia Emanuela Andrei, Ilinca Mihailescu, Alexandra Mariana Buica, Florina Rad   +4 more
doaj   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Predictive ability of anger on school anxiety chilean students of Secondary Education [PDF]

, 2015
La ira y la ansiedad están relacionadas a través de la vulnerabilidad biológica subyacente en ambos constructos, ya que los individuos reaccionan ante una amenaza con ira o ansiedad. Pero ¿tiene la ira la capacidad para predecir la ansiedad?
García Fernández, José Manuel, Gonzálvez Macià, Carolina, Inglés Saura, Cándido J., Lagos San Martín, Nelly, Vicent Juan, María   +4 more
core   +2 more sources

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Understanding the role of cognitive appraisal and mindfulness in driving-related anger among Chinese drivers

Transportation Research Interdisciplinary Perspectives
Cognitive appraisal plays an important role in driving anger, but it is unclear how drivers evaluate different anger-provoking situations. Also, mindfulness is regarded as a promising emotional regulation strategy, but its associations with state driving
Chenzhao Zhai, Samantha Jamson, Zahara Batool   +2 more
doaj   +1 more source

Causal analysis of multidimensional school anger among elementary and junior high school children [PDF]

, 2013
The purpose of this study was to examine causal relationships between three aspects of children\u27s anger (emotion, cognition, and behavioral expression), using two-wave panel design.
下田 芳幸, 寺坂 明子
core  

Women, anger, and aggression an interpretative phenomenological analysis [PDF]

, 2008
This study reports a qualitative phenomenological investigation of anger and anger-related aggression in the context of the lives of individual women. Semistructured interviews with five women are analyzed using interpretative phenomenological analysis ...
Burbank, V.K., Cox, D.L., Crawford, J., Eisikovits, Z., Gardner, G., Gendlin, E.T., Greenfield, L.A., Haug, F., Jonathan A. Smith, Maccoby, E.E., May, R., Novaco, R.W., Owens, L., Rachel Shaw, Reid, K., Smith, J.A., Solomon, R.C., Spielberger, C.D., Straus, M. A.,, Strongman, K., Vingerhoets, A.J.J., Virginia Eatough, Williams, D.G.   +22 more
core   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Anger and assaultiveness of male forensic patients with developmental disabilities : links to volatile parents [PDF]

, 2008
This study with 107 male forensic patients with developmental disabilities investigated whether exposure to parental anger and aggression was related to anger and assaultiveness in a hospital, controlling for background variables.
Novaco, Raymond, Taylor, John
core   +1 more source