Results 141 to 150 of about 91,055 (253)

CYP2C19 Polymorphisms and Clinical Outcomes Following Percutaneous Coronary Intervention in the Million Veteran Program

Clinical Pharmacology &Therapeutics, Volume 118, Issue 4, Page 876-884, October 2025.
CYP2C19 loss‐of‐function (LOF) alleles decrease the antiplatelet effect of clopidogrel following percutaneous coronary intervention (PCI) in patients presenting with acute coronary syndrome (ACS). The impact of genotype in patients undergoing PCI for stable ischemic heart disease (SIHD) in real‐world populations is less clear.
Catherine Chanfreau‐Coffinier, Kevin A. Friede, Mary E. Plomondon, Kyung Min Lee, Zhenyu Lu, Tia Dinatale, Scott L. DuVall, Jason L. Vassy, Stephen W. Waldo, John H. Cleator, Thomas M. Maddox, Daniel J. Rader, Themistocles L. Assimes, Scott M. Damrauer, Philip S. Tsao, Kyong‐Mi Chang, Deepak Voora, Julie A. Lynch, Jay Giri, VA Million Veteran Program, Sony Tuteja   +20 more
wiley   +1 more source

HEART Camp Connect—Promoting adherence to exercise in adults with heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 5, Page 3388-3398, October 2025.
Abstract Aims Most adults with stable heart failure are safe to exercise at a moderate intensity for 150 min/week. Regular participation in exercise may improve outcomes in adults with heart failure with preserved ejection fraction (HFpEF). Few adults with HFpEF initiate and sustain long‐term exercise. To promote exercise adherence in adults with HFpEF,
Windy W. Alonso, Sara E. Bills, Scott W. Lundgren, Steven J. Keteyian, Joseph Norman, Alfred L. Fisher, Cheng Zheng, Kevin A. Kupzyk, Fernando A. Wilson, Tiffany J. Dudley, Bunny J. Pozehl   +10 more
wiley   +1 more source

USE OF AFM FOR MORPHO-FUNCTIONAL STATE DIAGNOSTICS OF PLATELETS OF PATIENTS WITH ISCHEMIC HEART DISEASE

Doklady Belorusskogo gosudarstvennogo universiteta informatiki i radioèlektroniki, 2019
Atomic force microscopy was used to identify the early stages of intravascular platelet activation in patients with stable angina and in patients with unstable ischemic heart disease to characterize hemostasiological status of the patients. A comparative
L. V. Kukharenko, S. A. Chizhik, E. S. Drozd, L. G. Gelis, I. V. Lazareva, E. A. Medvedeva   +5 more
doaj  

Angiotensin receptor‐neprilysin inhibitors in concurrent heart failure with reduced ejection fraction and kidney failure

ESC Heart Failure, Volume 12, Issue 5, Page 3405-3415, October 2025.
Abstract Aims Angiotensin receptor‐neprilysin inhibitor (ARNI) therapy has demonstrated improved outcomes in heart failure with reduced ejection fraction (HFrEF). However, its benefits in patients with concomitant kidney failure undergoing replacement therapy remain uncertain. Methods and results Using the National Health Insurance Service database, we
Mi‐Hyang Jung, Dong‐Hyuk Cho, Jimi Choi, Mi‐Na Kim, Chan Joo Lee, Jung‐Woo Son, Yaeni Kim, Jong‐Chan Youn, Byung‐Su Yoo   +8 more
wiley   +1 more source

Impact of Frailty on Hospital Adverse Outcomes in Elderly With Acute Coronary Syndrome

Lifestyle Medicine, Volume 6, Issue 4, October 2025.
ABSTRACT Introduction Frailty management in acute coronary syndrome (ACS) patients remains a challenge due to the absence of standard guidelines, and the evidence of frailty in ACS elderly Vietnamese individuals is limited. This research aims to describe the impact of frailty on hospital adverse outcomes in older people with ACS in Vietnam.
Giang Song Tran, Anh Phuong Nguyen, Hung Manh Pham, Thanh Xuan Nguyen, Thu Thi Hoai Nguyen, Tam Ngoc Nguyen, Huong Thi Thu Nguyen, Hoa Trung Dinh, Huong Thi Thanh Nguyen, Anh Trung Nguyen, Quang Ngoc Nguyen, Huyen Thi Thanh Vu   +11 more
wiley   +1 more source

Acute Myocardial Infarction: Molecular Pathogenesis, Diagnosis, and Clinical Management

MedComm, Volume 6, Issue 10, October 2025.
Key pathogenic mechanisms in AMI. Oxidative stress and mitochondrial dysfunction induce ROS accumulation, while DAMPs‐PRRs interaction triggers inflammatory cascades. Programmed cell death pathways and epigenetic regulation collectively constitute the core components of AMI pathogenesis.
Mengmeng Zhu, Yiwen Li, Qian Xu, Wenting Wang, Yanfei Liu, Yue Liu   +5 more
wiley   +1 more source

Tirzepatide for the Maintenance of Body Weight Reduction: Rationale, Design, and Baseline Characteristics of SURMOUNT‐MAINTAIN

Obesity, Volume 33, Issue 10, Page 1873-1885, October 2025.
ABSTRACT Objective SURMOUNT‐MAINTAIN aims to evaluate the efficacy and safety of reducing the tirzepatide dose and/or continuing the maximum tolerated dose (MTD) versus placebo in maintaining body weight (BW) reduction achieved with tirzepatide MTD. Methods This Phase 3b, multicenter, randomized, parallel‐arm, double‐blinded, placebo‐controlled, 52 ...
Deborah B. Horn, Louis J. Aronne, Sean Wharton, Harold E. Bays, Elisa Gomez‐Valderas, Avigdor D. Arad, Palash Sharma, Julia P. Dunn, Cagri Senyucel, Clare J. Lee   +9 more
wiley   +1 more source

Preinfarction angina protects against in-hospital adverse outcomes in the elderly

Current Controlled Trials in Cardiovascular Medicine, 2001
Lyford Joanna, Navarro MJ, Gomez-Doblas JJ, Alonso-Briales J, Garcia JM, Gomez G, Alcantara AG, Rodriguez-Bailon I, Barrera A, Montiel A, Caliani JS, de Teresa E   +11 more
doaj   +1 more source

Platelet Activity And Some Immunological Findings In Atherosclerosis and Coronary Heart Disease

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
The   platelet  activity  and  some  immunological  aspects  of coronary heart disease CIID were investigated by employing platelet count and serum levels of IgG,IgM and lgA,C3 and C4.Three groups of  patients were investigated : patients with ...
A.I.S AI-Assaf
doaj  

Study Design and Rationale for The Breathe Easier With Tadalafil Therapy for Exercise‐Related Dyspnea in COPD‐PH (BETTER COPD‐PH)

Pulmonary Circulation, Volume 15, Issue 4, October 2025.
ABSTRACT Dyspnea, a debilitating symptom of COPD, worsens health‐related quality of life (HRQL), reduces daily physical activity, increases health care utilization, and is more closely associated with survival than airflow limitation. Thus, having treatments that reduce dyspnea in COPD is important.
Elena DeSanti, Matthew Jankowich, Gaurav Choudhary, Alan Morrison, Zachary K. Stanley, Eric Garshick, Marilyn L. Moy, Mohleen Kang, Cherry Wongtrakool, Ruxana T. Sadikot, Edward C. Dempsey, Matthew Griffith, Duc M. Ha, Christopher H. Schmid, Ronald H. Goldstein, Sharon Rounds, the BETTER COPD‐PH Study Group, Jayashri Aragam, Brack Hattler, Tim Lahm, Kristin L. Bailey, Debra Romberger, Gautam Kumar, Joshua Detelich, Jussi Saukkonen, Emily Wan, Shelsey Johnson, Malisa Barber, Christopher Halladay, Kathleen LaCerda, Renee LeClaire, Alexis Thavenet, Makkawi Makkawi, Mehret Tekle, Susan Burbach, Jenna Eggert, Julia Gillotti, Sridhar Tanukonda, Tiffany Elliott, Radhika Mungara, Matthew Lejy   +40 more
wiley   +1 more source