Results 11 to 20 of about 99 (99)
Advanced Science, EarlyView.This work designs an in situ proliferating peptide nanoparticle as a flexible resolution that modulates the neuro‐glia unit to enable enhanced multi‐target combinational therapy for secondary brain damage following subarachnoid hemorrhage. Abstract Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered ...
Yibin Zhang +8 more
wiley +1 more source
Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection
Advanced Science, EarlyView.The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng +10 more
wiley +1 more source
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source
Advanced Science, EarlyView.The fast adaptive focus tracking robotic optical coherence tomography (FACT‐ROCT) offers real‐time, high‐resolution imaging of spinal cord tumors during surgery. By reducing motion artifacts with robotics and adaptive focal tracking, it accurately differentiates tumor grades using a novel attenuation coefficient marker and reveals critical ...
Bin He +16 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.Conversion surgery for HCC. ABSTRACT Background Since 2013, we have performed conversion surgery after hepatic arterial infusion chemotherapy (HAIC) for initially unresectable locally advanced hepatocellular carcinoma (LA‐HCC). Methods Between 2013 and 2021, we assessed the surgical and oncological outcomes and pathological findings of patients with LA‐
Yuichi Goto +9 more
wiley +1 more source
Two‐Stage Treatment for Adult Large Patent Ductus Venosus
Annals of Gastroenterological Surgery, EarlyView.This is the first report of a two‐stage treatment for an adult large PDV involving the first stage surgical angioplasty of the large Arantius' duct and second stage embolization of the formed small Arantius' duct. The two‐stage approach could avoid embolic material migration into the systemic circulation or acute portal hypertension associated with the
Shohei Kudo +4 more
wiley +1 more source
An NIR‐III 3P Excitable AIE Nanoprobe for High‐Quality Intravital Deep‐Brain Angiography
Aggregate, EarlyView.A robust NIR‐III 3P excitable AIE probe was developed based on the proposed design strategy of π‐bridge manipulation to reconcile competing molecular parameters and optimize 3P fluorescence properties, which achieved optimal quality in intravital deep‐brain angiography among all reported organic 3P probes in terms of vascular imaging depth, SBR ...
Zhijun Zhang +8 more
wiley +1 more source
Mesenteric thrombosis: An unusual complication of severe acute pancreatitis—Report of two cases
Advances in Digestive Medicine, EarlyView.Abstract The incidence of acute pancreatitis is 34 per 100 000 people in the general population and is on the rise. Approximately 15% to 20% of all patients experience severe pancreatitis, with a mortality rate nearing 20%. This condition is often linked to vascular complications, although mesenteric thrombosis is a rare presentation.
Asya Zubillaga‐Mares +5 more
wiley +1 more source
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo +3 more
wiley +1 more source
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.An electromagnetic manipulation system enhances magnetic field strength in the Z‐direction for 3D control of microrobots and nanoparticles. Featuring eight metal‐core coils and two air‐core coils arranged hemispherically, it ensures unimpeded workspace access and integrates imaging tools.
Nader Latifi Gharamaleki +4 more
wiley +1 more source