Results 41 to 50 of about 16,532 (169)

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Myeloid cell leukaemia‐1 (MCL‐1) is an essential anti‐apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL‐1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardiotoxicity.
Markus B. Heckmann, Zsanett Papdi, Nils J. Strauch, Daniel Finke, Marc‐Steffen Raab, Antje Blank, Norbert Frey, Lorenz H. Lehmann   +7 more
wiley   +1 more source

Prof. Armando Mansilha

Gazeta Médica, 2017
• Professor of Angiology and Vascular Surgery of the Faculty of Medicine of University of Porto • Head of the Department of Angiology and Vascular Surgery at Hospital CUF Porto • Secretary General of the Section and Board of Vascular Surgery of the ...
Armando Mansilha, MD, PhD, FEBVS
doaj   +2 more sources

Vascular alterations among male elite athletes recovering from SARS-CoV-2 infection

Scientific Reports, 2022
SARS-CoV-2 may affect the cardiovascular system and vascular impairment has been reported in healthy young adults recovering from COVID-19. However, the impact of SARS-CoV-2 infection on the vascular function of elite athletes is unknown.
Pascal Bauer, Lutz Kraushaar, Oliver Dörr, Stanislav Keranov, Holger Nef, Christian W. Hamm, Astrid Most   +6 more
doaj   +1 more source

Association of altered body composition with cardiac wasting in cancer with and without cardiotoxic therapy

British Journal of Pharmacology, EarlyView.
Created in BioRender: Scientific Figure and Illustration Software. Background and Purpose In advanced cancer, associations among changes in body composition, cardiac wasting and prior cardiotoxic anticancer therapy have not been investigated. Experimental Approach Using bioelectrical impedance analysis (BIA), body composition was measured in 206 ...
Sara Hadzibegovic, Jonathan L. Hella, Jan Porthun, Alessia Lena, Danara Krug, Iulia Baluta, Ursula Wilkenshoff, Amir A. Mahabadi, Matthias Totzeck, Tienush Rassaf, Stefan D. Anker, Wolfram Doehner, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Barry J. A. Laird, Richard J. E. Skipworth, John G. F. Cleland, Christian Oeing, Stephan von Haehling, Ulf Landmesser, Markus S. Anker   +21 more
wiley   +1 more source

Predicting the Long‐Term Risk of Type 2 Diabetes and Cardiovascular Disease With Orforglipron in People With Overweight or Obesity: A Post Hoc Analysis of the ATTAIN‐1 Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective To assess change in long‐term predicted 10‐year cardiometabolic risk (Type 2 diabetes [T2D] and cardiovascular disease [CVD]) in adults with overweight or obesity without T2D. Methods This post hoc analysis used data from ATTAIN‐1, a Phase 3 trial in adults (≥ 18 years) with obesity (BMI ≥ 30 kg/m2) or overweight (BMI ≥ 27 kg/m2 with
Shraddha Shinde, Florian Kahles, Simona Vasileva‐Metodiev, Ryan Griffin, Hong Liu‐Seifert, Jeremie Lebrec, Neena A. Xavier, Runjia Li, Suzanne R. Klise, Ambrish Singh, Jens Aberle   +10 more
wiley   +1 more source

Attenuating Effects of Anti-Arrhythmic Agents on Changes in Fibrillation Cycle Length in Very Early Phase Paroxysmal Atrial Fibrillation —Spectral Analysis of Fibrillation Waves in Surface ECG—

Journal of Arrhythmia, 2009
Background: Antiarrhythmic agents may affect electrical remodeling but little is known regarding clinical cases. We evaluated fibrillation cycle length (FCL) of atrial fibrillation (AF) by spectral analysis of fibrillation waves (FW) in surface ECG for ...
Hidehira Fukaya, MD, Shinichi Niwano, MD, Takeshi Sasaki, MD, Michiro Kiryu, MD, Sayaka Kurokawa, MD, Yuko Hatakeyama, MD, Daisuke Sato, MD, Yoshihiro Yumoto, MD, Masahiko Moriguchi, MD, Hiroe Niwano, MD, Akira Fujiki, MD, Tohru Izumi, MD   +11 more
doaj   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

Modelo de suprimento sanguíneo do intestino delgado e grosso da preguiça de coleira (Bradypus torquatus) Blood supply model of the small and large intestine of the maned three-toed sloth (Bradypus torquatus)

Ciência Rural, 2013
O Bradypus torquatus, conhecido como preguiça de coleira, está classificado na lista vermelha da IUCN como vulnerável. Este animal é um folívoro estrito que se alimenta de um pequeno número de plantas. O suprimento sanguíneo do intestino delgado e grosso
Jussara Rocha Ferreira, Lorenna Cardoso Rezende, Phellip Carvalho, Amanda Rocha Mortoza, Daniele dos Santos Martins   +4 more
doaj  

Pharmacotherapy of chronic vein diseases. New European guidelines

Амбулаторная хирургия, 2018
The 19th Annual Meeting of the European Venous Forum held in the city of Athens in 28-30 June 2018 presented the long-awaited updated guidelines for the diagnosis and treatment of chronic venous diseases (CVD), the full text of which can be found in the ...
V. Yu. Bogachev, S. V. Rodionov, O. V. Dzhenina   +2 more
doaj   +1 more source

Anatomical Determinants of the Left Atrial Electrograms: Wall Thickness and Myocardial Fat Infiltration

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Electrogram peak‐to‐peak voltage depends on atrial wall structure and mapping configuration. We evaluated the relationship between computed tomography–derived atrial wall thickness, intramyocardial fat, myocardial muscle thickness, and electrogram voltage obtained with omnipolar, bipolar, and unipolar mapping.
Cecilia Granata, Nicola Pierucci, Lorenzo Mazzocchi, Raimondo Pittorru, Roger Borras, Jean‐Baptiste Guichard, Mariona Regany‐Closa, Jana Reventos‐Presmanes, Laia Llorca, Rosa Maria Figueras i Ventura, Jose Maria Tolosana, Adelina Doltra, Susana Prat, Blanca Domenech‐Ximenos, Rosario Jesus Perea‐Palazon, Till Althoff, Lluís Mont, Eduard Guasch, Marta Sitges, Ana Garcia‐Alvarez, Ivo Roca‐Luque, Andreu Porta‐Sanchez   +21 more
wiley   +1 more source