Results 111 to 120 of about 55,141 (338)

Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease [PDF]

, 2010
Because regional blood flow increases in association with the increased metabolic demand generated by localised increases in neural activity, functional imaging researchers often assume that changes in blood flow are an accurate read-out of changes in ...
Attwell, D., Hall, C.N., Hamilton, N.B.
core   +3 more sources

A unified 3D reconstruction of microscopy and MRI in a brain showing Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Post mortem MRI was combined with neuropathological assessments at 600 μm intervals throughout the brain. Through this approach, a three dimensional account of an entire human brain with an intermediate Alzheimer's disease neuropathologic change was created.
Anneke Alkemade, Pierre‐Louis Bazin, Evgeniya Kirilina, Kerrin Pine, Andreas Herrler, Ronald L. A. W. Bleijs, J. Max Kros, Lysanne Groenewegen, Sanne M. M. Vermorgen, Laura E. Jonkman, Dick F. Swaab, Rawien Balesar, Nikolaus Weiskopf, Birte U. Forstmann   +13 more
wiley   +1 more source

Effective protective mechanisms of HO-1 in diabetic complications: a narrative review

Cell Death Discovery
Diabetes mellitus is a metabolic disorder with persistent hyperglycemia caused by a variety of underlying factors. Chronic hyperglycemia can lead to diverse serious consequences and diversified complications, which pose a serious threat to patients ...
Jing-jing Zhang, Ping Ni, Yi Song, Man-jun Gao, Xi-ying Guo, Bao-qing Zhao   +5 more
doaj   +1 more source

Screening for Familial APP Mutations in Sporadic Cerebral Amyloid Angiopathy [PDF]

, 2010
Background Advances in genetic technology have revealed that variation in the same gene can cause both rare familial and common sporadic forms of the same disease.
A Rovelet-Lecrux, AL Gloyn, Alessandro Biffi, Anna Plourde, B Rosner, C Nilsberth, Christoph Winkler, Claudia M. Prada, D Woo, DA Nickerson, E Bakker, EE Smith, Eric E. Smith, James Gusella, JC Cohen, JC Florez, Jonathan Rosand, JP Vonsattel, KA Knudsen, L Hendriks, L Miravalle, L Obici, M Vaxillaire, Matthew Frosch, MS Fernando, Robert Onofrio, SM Greenberg, Steven M. Greenberg, SX Zhang-Nunes, TJ Grabowski, Yiping Shen, YW Chen   +31 more
core   +3 more sources

Sialylation patterns in cerebral amyloid angiopathy

Brain Pathology, EarlyView.
This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau, Rebecca Crisp, Mallory Keating, Elizabeth Ochoa, Timothy E. Richardson, Margaret E. Flanagan, Jamie M. Walker, Sarah C. Hopp, Kevin F. Bieniek   +8 more
wiley   +1 more source

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, EarlyView.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source

Frequência e fatores relacionados ao índice tornozelo-braquial aberrante em diabéticos

Jornal Vascular Brasileiro
Resumo Contexto O índice tornozelo-braquial (ITB) é um exame de rastreamento da doença arterial obstrutiva periférica, sendo também utilizado para avaliar o risco cardiovascular.
Ana Luisa Guimarães Siqueira de Araújo, Cícero Fidelis, Vanessa Prado dos Santos, José Siqueira de Araújo Filho, Jacy Andrade, Marco Antônio Vasconcelos Rêgo   +5 more
doaj   +1 more source

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI–neuropathology diagnostic accuracy study

Lancet Neurology, 2022
A. Charidimou, G. Boulouis, M. Frosch, J. Baron, M. Pasi, J. Albucher, G. Banerjee, Carmen Barbato, F. Bonneville, S. Brandner, L. Calvière, F. Caparros, B. Casolla, C. Cordonnier, M. Delisle, V. Deramecourt, M. Dichgans, Elif Gokcal, J. Herms, M. Hernández-Guillamon, H. Jäger, Z. Jaunmuktane, J. Linn, S. Martinez-Ramirez, E. Martínez-Sáez, C. Mawrin, J. Montaner, S. Moulin, J. Olivot, F. Piazza, L. Puy, N. Raposo, M. Rodrigues, S. Roeber, J. R. Romero, N. Samarasekera, J. Schneider, S. Schreiber, F. Schreiber, Corentin Schwall, Colin Smith, L. Szalardy, P. Varlet, A. Viguier, J. Wardlaw, Andrew D. Warren, F. Wollenweber, M. Zedde, M. Buchem, M. Gurol, A. Viswanathan, R. Salman, E. Smith, D. Werring, S. Greenberg   +54 more
semanticscholar   +1 more source

Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum [PDF]

, 2005
In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease ...
Cruts, Marc, Dermaut, Bart, Kumar-Singh, Samir, Rademakers, Rosa, Theuns, Jessie, Van Broeckhoven, Christine   +5 more
core   +1 more source

Alzheimer's disease and mixed pathologies as a hidden contributor to fatal hypothermia: A large‐scale forensic autopsy‐based study

Brain Pathology, EarlyView.
We investigated neuropathological manifestations of hypothermia in 168 cases. Patients aged 65 years or more constituted 80% of the total cohort. Alzheimer's disease was the most common comorbidity, affecting 40% of all patients. Abstract There is a paucity of autopsy‐based studies providing detailed neuropathological characteristics of fatal ...
Shojiro Ichimata, Koji Yoshida, Ryo Tanaka   +2 more
wiley   +1 more source