Results 121 to 130 of about 42,626 (296)

Therapeutic and Diagnostic Roles of MSC‐Derived Exosomes in Alzheimer's Disease

Brain and Behavior, Volume 15, Issue 12, December 2025.
Mesenchymal stem cell (MSC)‐derived exosomes deliver bioactive cargos, including miRNAs, neurotrophic factors, and antioxidant molecules, that modulate neuronal survival, microglial phenotype, and amyloid plaque clearance in Alzheimer's disease. These actions reduce apoptosis, oxidative stress, and inflammation, promote neurogenesis, enhance Aβ ...
Vinay Shankar Patil, Bhavin Parekh, Amit Sharma, Husni Farah, Renuka Jyothi‐S, Swati Mishra, Anima Nanda, Shaker Al‐Hasnaawei, Manoj Kumar‐Mishra   +8 more
wiley   +1 more source

Cerebral amyloid angiopathy-related infarcts imitating high-grade differentiation of a benign meningioma [PDF]

, 2015
Piotr Talarczyk, Avinash Kumar Kanodia, James W. Ironside, David Mowle   +3 more
openalex   +1 more source

The Use of Parabulbar and Sub‐Tenon Injections to Correct Isolated Resistant Diplopia in Patients With Generalized Myasthenia Gravis: A Long Road to Clinically Meaningful Success

Clinical Case Reports, Volume 13, Issue 12, December 2025.
Changes in ocular alignment following parabulbar betamethasone in myasthenia gravis. Paired images obtained before and after parabulbar betamethasone (0.5 mL per eye; April 22 and May 6, 2025) demonstrate improved horizontal alignment and reduction of vertical deviations in primary gaze, upgaze, right gaze, and left gaze.
M. Marchuk, V. Sanin, V. Mamilov, M. Zinchenko   +3 more
wiley   +1 more source

P2‐323: Toll‐like receptor 9 stimulation via CpG ODN in a non‐human primate model of sporadic cerebral amyloid angiopathy [PDF]

, 2015
Henrieta Scholtzova, Pramod N. Nehete, Bharti P. Nehete, Melanie M. Mallory, Elizabeth Cho, Andrea Holmes, Jina Park, Melinda Wren, Paige Pardington, Goutam Gupta, Pankaj Mehta, Lawrence E. Williams, Thomas Wısnıewskı   +12 more
openalex   +1 more source

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The limited clinical efficacy of anti‐Aβ antibodies has challenged the Aβ hypothesis, compelling the integration of key mechanisms—including neuroinflammation, mitochondrial dysfunction, oxidative stress, and post‐translational modifications of Aβ—into a revised model of Alzheimer's disease.
Shamseddin Ahmadi, Shiler Khaledi, Kimia Ahmadi, Kambiz Hassanzadeh   +3 more
wiley   +1 more source

Mesenchymal stem cells overexpressing XIST induce macrophage M2 polarization and improve neural stem cell homeostatic microenvironment, alleviating spinal cord injury

Journal of Tissue Engineering
Spinal cord injury (SCI) is a significant cause of disability worldwide, with limited treatment options. This study investigated the potential of bone marrow-derived mesenchymal stem cells (BMSCs) modified with XIST lentiviral vector to modulate ...
Dan Zhu, Tie Peng, Zhenwang Zhang, Shuang Guo, Ying Su, Kangwei Zhang, Jiawei Wang, Chao Liu   +7 more
doaj   +1 more source

Red Wine May Mitigate the Risk of Intracerebral Hemorrhage by Preventing Hypertension—A Mendelian Randomization Study Combining CHARLS

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study shows alcohol increases intracerebral hemorrhage risk (OR = 1.21), while red wine reduces it (two‐sample MR OR = 0.61; multivariable MR OR = 0.55), partly via lowering hypertension (mediation = 13.45%). CHARLS data find wine drinkers (especially elderly males) have lower hypertension (OR = 0.54), and this holds after multivariable logistic ...
Fuan Zhang, Ning Ding, Lanying Zhang, Ping Zhang, Rui Liu, Ziqiang Chen, Jiao Chen, Huanhuan Li, Shengtao Yao   +8 more
wiley   +1 more source

Schisandrin A ‌ameliorates the diabetes-associated memory impairment by alleviating inflammation and ferroptosis

Acta Biochimica et Biophysica Sinica
Schisandrin A (SchA), a bioactive lignan that was isolated from the dried fruit of Schisandra chinensis, has attracted much attention because of its diverse spectrum of pharmacological effects.
Ma Guandi, Lei Min, Guo Shuang, Zhang Yuqing, Sun Yixuan, Ji Huimin, Ouyang Changhan, Yang Xiaosong, Zhang Youzhi, Liu Xiufen, Zhao Baoqing, Guo Xiying   +11 more
doaj   +1 more source

Causal Relationship Between Circulating Omega‐3 Fatty Acid and Cerebral Small Vessel Disease: A Mendelian Randomization Study

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This Mendelian randomization study demonstrated that higher circulating omega‐3 fatty acid levels were causally associated with a modest reduction in risk of cerebral microbleeds (CMB). No significant associations were observed for other CSVD phenotypes, including WMH, LS, and WMPVS.
Yaodan Zhang, Lingxue Gong, Xinmin Deng, Jingtao Liang, Xiaofeng Lv, Rui Lai, Meijun Liu   +6 more
wiley   +1 more source

Advanced Mass Spectrometry-Based Biomarker Identification for Metabolomics of Diabetes Mellitus and Its Complications

Molecules
Over the years, there has been notable progress in understanding the pathogenesis and treatment modalities of diabetes and its complications, including the application of metabolomics in the study of diabetes, capturing attention from researchers ...
Feixue Zhang, Shan Shan, Chenlu Fu, Shuang Guo, Chao Liu, Shuanglong Wang   +5 more
doaj   +1 more source