Results 71 to 80 of about 55,141 (338)
Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy
Journal of Alzheimer's Disease, 2020 Background: There is limited data on cerebrospinal fluid (CSF) biomarkers in sporadic amyloid-β (Aβ) cerebral amyloid angiopathy (CAA). Objective: To determine the profile of biomarkers relevant to neurodegenerative disease in the CSF of patients with ...
G. Banerjee +14 more
semanticscholar +1 more source
Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. [PDF]
, 2009 Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
Jagust, WJ, Rabinovici, GD
core +2 more sources
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, EarlyView.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
Cerebral Hypoperfusion and the Energy Deficit in Alzheimer's Disease [PDF]
, 2016 There is a perfusion deficit in Alzheimer's disease (AD), commencing in the precuneus and spreading to other parts of the cerebral cortex. The deficit anticipates the development of dementia, contributes to brain damage, and is caused by both functional ...
Love, Seth, Miners, J. Scott
core +4 more sources
Research progress of brain organoids in the field of diabetes
Molecular BrainHuman embryonic stem cells and human induced pluripotent stem cells may be used to create 3D tissues called brain organoids. They duplicate the physiological and pathological characteristics of human brain tissue more faithfully in terms of both ...
Ying Su +10 more
doaj +1 more source
Intracranial Hemorrhage Due to Secondary Hypertension from Intracranial Large Vessel Occlusion [PDF]
, 2020 Simultaneous hemorrhagic and ischemic strokes have been previously reported in the literature. Typically, these occur in patients secondary to dialysis, cerebral amyloid angiopathy, or thrombotic thrombocytopenic purpura.1,2,3 However, this is the unique
Khan, Asif A. +3 more
core
Cerebral Microbleeds in a Stroke Prevention Clinic. [PDF]
, 2019 The objective of this study is to assess the effectiveness of a stroke clinic in stroke prevention and progression of cerebral microbleeds (CMB). We conducted a retrospective observational study of patients who visited a stroke clinic between January ...
Chang, Peter +7 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady +5 more
wiley +1 more source
Some aspects of morphogenesis of diabetic encephalopathy
Zaporožskij Medicinskij Žurnal, 2013 On the basis of the literary data and conducted large-scale research it was ascertained that diabetes mellitus raises the risk of cerebral stroke in 2-6 times, the risk of transitional ischemic attacks in 3 times in comparison with the same risk in the ...
V. A. Tumanskiy, Yu. N. Avramenko
doaj +1 more source
Emerging concepts in sporadic cerebral amyloid angiopathy.
Brain : a journal of neurology, 2017 Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and a largely untreatable cause of intracerebral haemorrhage and contributor to age-related cognitive decline.
A. Charidimou +7 more
semanticscholar +1 more source