Results 311 to 320 of about 4,861,792 (337)

Effect of angiotensin II and an angiotensin II inhibitor on renin secretion in the dog

American Journal of Physiology-Legacy Content, 1975
This study examined the effect of angiotensin II (AII) and (Sar-1Gly-8) AII, a competitive inhibitor of AII, on renin release in anesthetized dogs. An intravenous infusion of AII (25 ng/kg per min) raised BP 24 mmHg and lowered plasma renin activity (PRA) from 18.8 plus or minus 2.8 to 6.2 plus or minus 1. 3 ng/ml per h (P smaller than .001). When the
S Taher, A De Torrente, Keith M. McDonald, G Aisenbrey, Robert W. Schrier   +4 more
openaire   +3 more sources

Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats

American Journal of Physiology-Renal Physiology, 2002
This study was designed to determine the involvement of AT1receptors in the uptake of ANG II in the kidney of rats exposed to differing salt intake. Male Wistar-Kyoto rats were treated with a normal-salt (NS; 1% NaCl, n = 7) or a low-salt (LS; 0.025% NaCl, n = 7) diet combined with (LS+Los, n = 7; NS+Los, n = 7) or without losartan (30 mg · kg−1· day−1)
Michèle Grima, Jean-Louis Imbs, Catherine Coquard, Mariette Barthelmebs, Catherine Ingert   +4 more
openaire   +3 more sources

Nitric oxide–angiotensin II interactions in angiotensin II‐dependent hypertension

Acta Physiologica Scandinavica, 2000
Many studies indicate that renal haemodynamic function in angiotensin II‐ (ANG II) dependent hypertension is not reduced as much as would be predicted from the elevated ANG II levels suggesting that counteracting renoprotective mechanisms are activated. One important renoprotective effect is mediated by increased levels of nitric oxide.
L. G. Navar, S Y Chin, John D. Imig, Atsuhiro Ichihara   +3 more
openaire   +3 more sources

Renal Accumulation of Circulating Angiotensin II in Angiotensin II–Infused Rats

Hypertension, 1996
Abstract Previous studies have demonstrated that low-dose angiotensin II (Ang II) infusion for 14 days mimics two-kidney, one clip Goldblatt hypertension and increases intrarenal Ang II levels. The objective of the present study was to determine whether the augmented intrarenal Ang II is due to intrarenal accumulation of the ...
L. Gabriel Navar, Anka Hymel, Li-Xian Zou, John D. Imig   +3 more
openaire   +3 more sources

Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization

Trends in Pharmacological Sciences, 2005
Angiotensin II and aldosterone produce pro-arrhythmic effects by several mechanisms, including the modulation of voltage-dependent K(+) channels involved in human cardiac repolarization. Drugs that inhibit the renin-angiotensin-aldosterone system exert anti-arrhythmic actions that are related to the blockade of the pro-arrhythmic actions of angiotensin
Lucía Núñez, Ricardo Gomez, Juan Tamargo, Ricardo Caballero, Eva Delpón   +4 more
openaire   +3 more sources

Augmentation of intrarenal angiotensin II levels by chronic angiotensin II infusion

American Journal of Physiology-Renal Physiology, 1994
The objective of this study was to investigate the singular role of elevated angiotensin II (ANG II) levels in the development of two-kidney, one-clip (2K1C) Goldblatt hypertension in the rat and specifically in the altered intrarenal ANG II levels that occur in the nonclipped kidney. As a substitute for the clipped kidney, chronic delivery of ANG II (
A M Von Thun, L. G. Navar, Richard C. Vari, Samir S. El-Dahr   +3 more
openaire   +3 more sources

RADIOIMMUNOASSAY OF ANGIOTENSIN II IN PLASMA

Acta Endocrinologica, 1969
ABSTRACT Specific antibodies were produced in rabbits with val5angiotensin II amid (Hypertensin®, Ciba) attached to succinyl-poly-l-lysine. Hypertensin was labelled with iodine-125 (125I) according to a modified Hunter-Greenwood procedure.
openaire   +3 more sources

Is the adrenal angiotensin receptor angiotensin II — or angiotensin III like?

Acta Endocrinologica, 1983
Abstract. In order to determine whether the adrenal receptor is primarily directed at angiotensin II (All) or angiotensin III (AIII) the following in vitro experiments were performed examining aldosterone responsiveness in isolated glomerulosa cells.
Richard H. Underwood, Lynne M. Braley, Gordon H. Williams, Alphonsa Menachery   +3 more
openaire   +3 more sources

Conformational study of angiotensin II

Biopolymers, 1996
Conformational free energy calculations using an empirical potential ECEPP/3 (Empirical Conformational Energy Program for Peptides, Version 3) were carried out on angiotensin II (AII) of sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe to find the stable conformations of the free state in the unhydrated and the hydrated states. A conformational analysis of the
Young Ah Shin, Sung-Eun Yoo
openaire   +3 more sources

Angiotensin II and angiotensin III in rat blood.

Circulation Research, 1976
Angiotensin II and its metabolites, [des-Asp-1]-angiotensin II (angiotensin III), [des-(Asp-1,Arg-2)]angiotensin II, and [des-(Asp-1,Arg-2,val-3)]angiotensin II, were measured in arterial and venous plasma from normal rats. Paper chromatography was used to separate the peptides which were measured with a radioimmunoassay method using an angiotensin II ...
P F Semple, J J Morton
openaire   +3 more sources