Results 51 to 60 of about 70,885 (289)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comparison of mandibular anterior vertical bone level between high-angle skeletal Class II malocclusion patients and high-angle skeletal Class III malocclusion patients (mm). [PDF]

, 2019
Comparison of mandibular anterior vertical bone level between high-angle skeletal Class II malocclusion patients and high-angle skeletal Class III malocclusion patients (mm).
Jing Ma (24574), Jiu-hui Jiang (6504269), Jing Huang (41604)   +2 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Comparison of maxillary anterior vertical bone level between high-angle skeletal Class II malocclusion patients and high-angle skeletal Class III malocclusion patients (mm). [PDF]

, 2019
Comparison of maxillary anterior vertical bone level between high-angle skeletal Class II malocclusion patients and high-angle skeletal Class III malocclusion patients (mm).
Jing Ma (24574), Jiu-hui Jiang (6504269), Jing Huang (41604)   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Correlation of tongue posture with dental arch characteristics in different skeletal patterns using cone-beam computed tomography

Journal of Dental School
  Objectives: This study assessed the correlation of tongue posture with dental arch characteristics in sagittal and vertical skeletal patterns using cone-beam computed tomography (CBCT). Materials and Methods: This cross-sectional study evaluated
Kazem Dalaie, Hamideh Zeinali, Mohammad Behnaz, Yaser Safi, Soodeh Tahmasbi, مریم صدیقی نیا   +5 more
doaj   +1 more source

Compensação ortodôntica no tratamento da maloclusão de Classe III [PDF]

, 2015
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.O presente trabalho de conclusão de curso tem por objetivo, através de revisão bibliográfica, apresentar o tratamento não cirúrgico, de pacientes que ...
Farias, Ane Caroline
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The effect of mentoplate application on the condyle

BMC Oral Health
Background The aim of the study was to investigate the changes occurring in the mandibular condyle by using mentoplate together with rapid maxillary expansion (MP-RME) treatment in the correction of skeletal class III relationship, using fractal analysis
Gorkem Tekin, Ayşe Tugce Ozturk Kocak, Batuhan Kuleli, Taner Ozturk, Omur Dereci, Nesrin Saruhan Kose, Mehmet Ugurlu, Yasin Caglar Kosar, Gizem Caliskan   +8 more
doaj   +1 more source