Results 41 to 50 of about 11,977 (251)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Participation in collaborative fisheries research improves the perceptions of recreational anglers towards marine protected areas

Frontiers in Marine Science
Collaborative fisheries research programs engage stakeholders in data collection efforts, often with the benefit of increasing transparency about the status and management of natural resources. These programs are particularly important in marine systems,
Erin M. Johnston, Grant T. Waltz, Grant T. Waltz, Rosamaria Kosaka, Ellie M. Brauer, Shelby L. Ziegler, Shelby L. Ziegler, Erica T. Jarvis Mason, Hunter S. Glanz, Lauren Zaragoza, Allison N. Kellum, Rachel O. Brooks, Rachel O. Brooks, Rachel O. Brooks, Brice X. Semmens, Christopher J. Honeyman, Jennifer E. Caselle, Lyall F. Bellquist, Lyall F. Bellquist, Sadie L. Small, Steven G. Morgan, Timothy J. Mulligan, Connor L. Coscino, Jay M. Staton, Jay M. Staton, Richard M. Starr, Scott L. Hamilton, Benjamin I. Ruttenberg, Dean E. Wendt   +28 more
doaj   +1 more source

Saltwater anglers' attitudes towards marine protected areas

, 2004
Attempts to establish “no-take” marine reserves in the United States have engendered strong opposition from sportfishing interest groups. This study investigated northeastern saltwater anglers' attitudes towards several hypothetical marine protected area
Salz, RJ, Loomis, DK
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

A coupled recreational anglers' decision and fish population dynamics model. [PDF]

PLoS ONE, 2018
The effective management of fish populations requires understanding of both the biology of the species being managed and the behavior of the humans who harvest those species.
Masami Fujiwara, Jesse D Backstrom, Richard T Woodward   +2 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The Effect of Angler Education Materials on the Practice of Selective Harvest: Evidence From a Survey Experiment

Aquaculture, Fish and Fisheries
Catch‐and‐release fishing campaigns have aided in fish conservation. In some cases, this success has perversely led to the decline of trophy fish via increased fish density.
Nathan W. Monroe, James F. Spriggs, Micheal S. Allen, Greg G. Sass   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source