Results 81 to 90 of about 3,274,537 (356)

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

open access: yesAdvanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso   +5 more
wiley   +1 more source

Numerical Studies of Influencing Factors on the Homogeneity of the Powder Mixture during the Powder Spreading Process of Powder Bed Fusion–Laser Beam/Metal

open access: yesAdvanced Engineering Materials, EarlyView.
AISI 304L stainless steel powder is mixed with silicon nitride (Si3N4) powder and processed by PBF‐LB/M, allowing partial retention of Si3N4. The numerical approach effectively predicts the Si3N4 powder homogeneity and N content distribution on the powder bed. Recent studies have focused on the alloying of nitrogen (N) in high‐alloy stainless steels by
Yuanbin Deng   +7 more
wiley   +1 more source

Association between the On-Plane Angular Motions of the Axle-Chain System and Clubhead Speed in Skilled Male Golfers

open access: yesApplied Sciences, 2020
The on-plane rotations of the inclined axle-chain system on the functional swing plane (FSP) can represent the angular motions of the golfer–club system closely.
Morgan V. Madrid   +5 more
doaj   +1 more source

Study of high-speed angular-contact ball bearings under dynamic load [PDF]

open access: yes, 1969
Research program studies behavior of specific high-speed, angular-contact ball bearings. Program is aimed at detailed investigation of ball-separator behavior and lubrication surface-finish effects in a specific gyro ...
Geer, T. E.   +4 more
core   +1 more source

Bridging Nature and Technology: A Perspective on Role of Machine Learning in Bioinspired Ceramics

open access: yesAdvanced Engineering Materials, EarlyView.
Machine learning (ML) is revolutionizing the development of bioinspired ceramics. This article investigates how ML can be used to design new ceramic materials with exceptional performance, inspired by the structures found in nature. The research highlights how ML can predict material properties, optimize designs, and create advanced models to unlock a ...
Hamidreza Yazdani Sarvestani   +2 more
wiley   +1 more source

Development of Ternary Magnesium Alloys for Laser Powder Bed Fusion: Optimizing Oxide Layer Thickness

open access: yesAdvanced Engineering Materials, EarlyView.
Additive manufacturing of magnesium alloys by laser is difficult because the melting point of the oxide layer is much higher than the evaporation temperature of the metal underneath. Making the oxide layer thinner can solve this problem. Alloying magnesium with strontium makes the oxide layer thinner, especially at 0.5 wt%.
Elmar Jonas Breitbach   +8 more
wiley   +1 more source

Angular momentum transfer in primordial discs and the rotation of the first stars

open access: yes, 2018
We investigate the rotation velocity of the first stars by modelling the angular momentum transfer in the primordial accretion disc.Assessing the impact of magnetic braking, we consider the transition in angular momentum transport mode at the Alfv$\acute{
Bromm, Volker, Hirano, Shingo
core   +1 more source

A Case‐Based Reasoning Approach to Model Manufacturing Constraints for Impact Extrusion

open access: yesAdvanced Engineering Materials, EarlyView.
A hybrid modeling approach is presented that combines constraint‐based process modeling and case‐based reasoning. The model formalizes manufacturing constraints and integrates simulation data to model complex manufacturing processes. The approach supports manufacturability analysis during product design through an adaptive modeling environment.
Kevin Herrmann   +5 more
wiley   +1 more source

Real-time Monitoring of Uncertainty due to Refraction in Multibeam Echo Sounding [PDF]

open access: yes, 2010
A software toolkit has been developed to objectively monitor uncertainty due to refraction in multibeam echosounding, specifically mapping systems that employ underway sound speed profiling hardware.
Beaudoin, Jonathan
core   +1 more source

Assessing the Ecological Value: Monetizing Process Innovations in Tailored Forming

open access: yesAdvanced Engineering Materials, EarlyView.
This article introduces a method for evaluating the sustainability of innovations, even with limited data. The method is illustrated through an analysis of the “Tailored Forming” technology, which explores the impact of sustainability on economic value added.
Jonas Schneider   +4 more
wiley   +1 more source

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