Results 111 to 120 of about 175,197 (281)
1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors [PDF]
, 1983 We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to ...
Asquith, Christopher R.M. +11 more
core +3 more sources
Advanced Science, EarlyView.A multifunctional vascular bed platform is created using coaxial 3D printing, allowing the one‐step integration of organoid microspheres with perfusable vascular structures. This strategy enables rapid and functional vascularization of organoids to support tissue repair and vascularization, providing a scalable and translationally promising approach ...
Kunrui Wang +10 more
wiley +1 more source
Advanced Science, EarlyView.A NETs‐inspired Ti3C2/LDH hydrogel integrates trapping, ROS boosting, and M2‐immunomodulation for MRSA‐infected wound repair. ABSTRACT MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis—conditions for which existing clinical interventions offer only limited efficacy. The utility
Qiang Shi +6 more
wiley +1 more source
Stable BF2 Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization
Angewandte Chemie, EarlyView.We report a robust, metal‐free and scalable synthesis of stable BF2 boracycles via directed ortho CH borylation, delivering isolable, shelf‐stable reagents without chromatographic purification. These BF2 boracycles exhibit unique and tunable reactivity, enabling highly selective ipso‐functionalization across a broad range of transformations.
Ganesh H. Shinde +11 more
wiley +2 more sources
Heterocycle-guided synthesis of m-hetarylanilines via three-component benzannulation
Beilstein Journal of Organic ChemistryA one-pot three-component synthesis of substituted meta-hetarylanilines from heterocycle-substituted 1,3-diketones has been developed. The electron-withdrawing power of the heterocyclic substituent (which can be estimated on the basis of calculated ...
Andrey R. Galeev +3 more
doaj +1 more source
Crystal structure of 2,3-bis[(4-tert-butyl-2,6-dimethylphenyl)imino]butane
Acta Crystallographica Section E: Crystallographic Communications, 2015 The title compound, C28H40N2, was obtained from the condensation reaction of 4-tert-butyl-2,6-dimethylaniline and butane-2,3-dione. The molecule lies on an inversion centre. The C=N bond has an E conformation.
Sheng-Lan Zhao, Jian-Chao Yuan, Yan Zhao
doaj +1 more source
Advanced Science, EarlyView.Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang +27 more
wiley +1 more source
Atroposelective Suzuki–Miyaura Coupling to Form 2‐Amino‐2′‐Hydroxybiphenyls Enabled by sRuPhos
Angewandte Chemie, EarlyView.We report a new chiral phosphine ligand, sRuPhos, which permits the highly enantioselective Suzuki–Miyaura coupling of ortho‐aniline and ortho‐phenol building blocks. This results in 2‐amino‐2′‐hydroxybiphenyls with very high enantiomeric excesses, products that will have application in pharmaceutical synthesis and ligand design for catalysis ...
Hamzah Sharif +3 more
wiley +2 more sources
Advanced Science, EarlyView.We report a general strategy for meta‐selective C–H arylation using aryl iodides and a Pd(II)/Pd(IV) catalytic system guided by a removable directing group. DFT and experimental studies reveal that counter anion tuning (acetate to trifluoroacetate) significantly enhances selectivity.
Jagrit Grover +6 more
wiley +1 more source
Double E─H Bond Activation of Ammonia and Water by Cyclic Gallaphosphene L(OCP)GaPGaL
Angewandte Chemie, EarlyView.Cyclic gallaphosphene 1 undergoes a twofold E─H bond activation with ammonia and water via a beneficial interplay between the polar “GaPGa” unit and the electrophilic nature of the C center in the bridging PCO unit, yielding six‐membered heterocycles 2 and 3, in which both nucleophilic phosphorus atoms are protonated.
Mahendra K. Sharma +3 more
wiley +2 more sources