Results 131 to 140 of about 149,644 (286)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

The Ensminger Program: Activities in International Animal Agriculture

, 2009
The Ensminger Program is an effort to improve and expand activities in international animal agriculture in the Department of Animal Science and the College of Agriculture and Life Sciences.
Rothschild, Max
core   +2 more sources

Healthcare professionals’ attitudes to animal assisted activity with dogs in paediatric care

Complementary Therapies in Clinical Practice
Hospitalization for children often involves stress induced by fear and pain. Complementary therapies, such as Animal Assisted Activities (AAA) with dogs, can alleviate the hospital experience.The first aim of this study was to initiate the development of an instrument that measures healthcare professionals' attitudes toward complementary therapy ...
M. Lindstrom Nilsson, K. Enskar, G. Engvall, A. Edner, E.-L. Funkquist   +4 more
openaire   +2 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Animal-Assisted Activities for Students with Disabilities: Obtaining Stakeholders’ Approval and Planning Strategies for Teachers

, 2014
Animal-human interactions have been found to have positive influences on children across the world. In particular, research supports the benefits of animal-assisted activities in addressing students\u27 social and behavioral problems within the classroom
Cho, Jeong il, Baumgartner, E
core  

Animal-assisted support programs for residents in Canadian long-term care homes: a feasibility and acceptability study

BMC Geriatrics
Background Animal-assisted services, specifically animal-assisted support programs (AASPs, pet therapy, animal-assisted therapy, animal-assisted activities), are promising programs that may improve the mental health and overall well-being of older adults
Brittany S. DeGraves, Hannah M. O’Rourke, Colleen Dell, Heather Titley, Carole A. Estabrooks   +4 more
doaj   +1 more source

“He's opening everybody's heart up”: Co-creating pet therapy activities with inpatients at a large urban mental health and addictions hospital

Social Sciences and Humanities Open
Background: Animal-Assisted Activities (AAA) is now ubiquitous in many health care settings around the world. There is growing evidence about AAA's benefits but there is no literature about the inclusion of patients, the end-user, in the design and ...
Laura Sikstrom, Chelcie Soroka, Csilla Kalocsai, Theresa Conforti, Eva Katz, Sophie Soklaridis   +5 more
doaj   +1 more source