Results 41 to 50 of about 6,379,052 (242)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Embodied regulation and connection in equine-assisted services: Advancing a somatic and relational informed model within a One Health and One Welfare framework

Human-Animal Interactions
Background: Horses Inspire, a phase-based curriculum that integrates therapeutic horseback riding and ground-based equine-assisted psychotherapy (EAP), is informed by somatic-based psychotherapy theories, with One Health and One Welfare principles ...
Kate Nicoll, Alison Simpson, Claire Burdick, Morgan Evans, Jean Ruggiero, Joelle Smorada   +5 more
doaj   +1 more source

Characterizing stress during animal interaction: a focus on the human endocrine response during equine-assisted services

Frontiers in Veterinary Science, 2023
Repeated stresses applied to the rider may contribute to the documented physical and psychosocial outcomes from equine-assisted services. In this brief review, a summary of neuroendocrine markers of stress, including immunoglobulin A, serotonin, cortisol,
Brandon R. Rigby, Brandon R. Rigby
doaj   +1 more source

Prediction of haplotypes for ungenotyped animals and its effect on marker-assisted breeding value estimation [PDF]

, 2010
Background: In livestock populations, missing genotypes on a large proportion of animals are a major problem to implement the estimation of marker-assisted breeding values using haplotypes.
Calus, M.P.L., Han A Mulder, Roel F Veerkamp, Veerkamp, R.F., Mulder, H.A., Mario PL Calus   +5 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Well-Being Indicators in Autistic Children and Therapy Dogs During a Group Intervention: A Pilot Study

Animals
Animal-assisted services (AAS) have been shown in multiple studies to improve a range of human psychological and physical health benefits. The aim of this pilot study is to investigate simultaneously two psycho-physiological indicators of the valence of ...
Viviana Orsola Giuliano, Luigi Sacchettino, Alina Simona Rusu, Davide Ciccarelli, Valentina Gazzano, Martina de Cesare, Michele Visone, Vincenzo Mizzoni, Francesco Napolitano, Danila d’Angelo   +9 more
doaj   +1 more source

Exploring the Social Reinforcing Value of Brushing in Equine-Assisted Services: A Comparative Study with Food Reinforcement

Human-Animal Interactions, 2023
Brushing is one of the most common human-horse interactions in Equine-Assisted Services (EAS). Previous research has shown both positive and negative effects of brushing on horses’ behavior and physiological states.
Katy Schroeder, Megan Arant, Cameron Hekkert, Alexandra Protopopova   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Comparative analysis of multiple stakeholder perspectives on the benefits of school-based therapy dogs at a special education school

Discover Animals
One response to the academic and mental health struggles of youth has been the introduction of therapy dogs in school settings. Animal-Assisted Services (AAS) describe processes where trained and registered dogs and their handlers collaborate with ...
Jean P. Kirnan, Olivia Sampson
doaj   +1 more source

Purpose through partnership: Understanding what drives volunteer engagement in animal-assisted services with dogs

Human-Animal Interactions
Background: Animal-assisted services (AAS), including therapy, education, and support programs, have become increasingly valued as a resource for improved human physical and emotional health. Despite this growth, little empirical attention has been given
Lori R. Kogan, Jennifer Currin-McCulloch, Emma Brown, Wendy Packman, Cori Bussolari   +4 more
doaj   +1 more source