Results 41 to 50 of about 146,853 (284)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Animal-assisted therapy using dogs: The benefits to children [PDF]

open access: yes, 2007
Includes bibliographical ...
Oian, Corrine E.
core  

Costs, benefits and mechanisms of animal-assisted therapy: adopting a change in perspective

open access: yesScottish Journal of Residential Child Care, 2018
Animal-assisted therapy has progressed in recent years, helping a broad spectrum of people to tackle stress, loneliness and health problems, including those with life-long disabilities.
Vanessa A. D. Wilson
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Animal-Assisted Therapy Supports Student Connectedness [PDF]

open access: yes, 2018
Animal-assisted therapy is a complementary approach to supporting the well-balanced student. In particular, therapy dogs in school can have a direct impact on students’ social interactions, class participation, and behavior, as well as strengthening ...
Jill Fedor
core   +1 more source

Feasibility of Animal-Assisted Therapy in the Treatment of Depression

open access: yesPsikiyatride Güncel Yaklaşımlar
The objective of this review is to assess the potential inclusion of animal-assisted therapy practices in the treatment of depression. Given the documented rise in the incidence of depression in recent years, there is a recognized significance in ...
Onour Impram, Fatima Zehra Allahverdi
doaj   +1 more source

Healing smiles: Enhancing pediatric dental care through animal-assisted therapy – A narrative review

open access: yesArchives of Medicine and Health Sciences, 2023
Dental anxiety refers to the negative emotional response of fear or avoiding dental care, which is exhibited by cognitive, physiological, and motor reactions when related to dental visits or dental treatment.
Aishwarya Vineshkumar Antala   +1 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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