Results 171 to 180 of about 4,423,174 (319)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Unifying two medicines to fight pain and to make anesthesia safer

Frontiers in Veterinary Science, 2023
Karine Portier, Karine Portier
doaj   +1 more source

'Helpful', 'Objective', and 'Useful': User Perceptions of the Animal Welfare Assessment Grid (AWAG) for Dogs as a Decision-Making Tool. [PDF]

Vet Med Sci
Malkani R, Paramasivam SJ, Wolfensohn S.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Corigendum to "Integrative genomic analysis and gene expression patterns reveal a cardio-neuroendocrine signaling network for heat adaptation in geographically diverse chickens" [Poultry Science, Volume 105, Issue 6, June 2026, 106744]. [PDF]

Poult Sci
Nawaz AH, Cui Q, Ding J, Ali S, Leng D, Mukhtar N, Setthaya P, Chaiwang N, Sheng Z, Li D, Tyasi TL, Zhao Y, Feng C.   +12 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Three-dimensional approaches to measuring primary cilia in hippocampal neurons: A comparative analysis. [PDF]

J Neuropathol Exp Neurol
Rasmusson S, Shiadeh SMJ, Dada N, Åkesson E, Mallard C, Ardalan M.   +5 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

FDA roadmap to reducing animal testing: a regulatory and scientific paradigm shift in nonclinical safety assessment. [PDF]

Stem Cell Res Ther
Lei Y, Tuan RS, Li ZA.
europepmc   +1 more source

ANIMAL EXPERIMENTS [PDF]

The Lancet, 1977
openaire   +2 more sources