Results 81 to 90 of about 2,928,935 (339)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Climate stability and societal decline on the margins of the Byzantine empire in the Negev Desert

Scientific Reports, 2020
Understanding past human settlement of inhospitable regions is one of the most intriguing puzzles in archaeological research, with implications for more sustainable use of marginal regions today.
Petra Vaiglova, Gideon Hartman, Nimrod Marom, Avner Ayalon, Miryam Bar-Matthews, Tami Zilberman, Gal Yasur, Michael Buckley, Rachel Bernstein, Yotam Tepper, Lior Weissbrod, Tali Erickson-Gini, Guy Bar-Oz   +12 more
doaj   +1 more source

Nature Conservation Advisory Service for Farmers - A New Approach to Integrate Nature Conservation on Farm Level [PDF]

, 2005
From a historical point of view, it is obvious that agriculture is responsible for building the cultural landscapes of Europe. In a process of hundreds of years, the natural landscapes had been replaced by cultural ones.
van Elsen, Thomas
core  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Legal protection of animals in Israel

Derecho Animal, 2017
Israel’s legislatures have been strongly promoting animal welfare and animal rights in recent decades, as lawmakers have united in giving increased importance to animal cruelty and suffering at the Knesset, in a country where the number of vegans is ...
Marine Lercier
doaj   +1 more source

Terminology on abandonment of domestic animals for use in Latin America

, 2022
El abandono de animales no humanos es un problema social mundial que afecta a todos los seres vivos y al medio ambiente, por lo que es un problema de Salud Única. Las investigaciones llevadas a cabo en todo el mundo tratan de comprender las causas de este abandono para poder llevar a cabo intervenciones eficaces.
Brugnerotto, Michele, Oliveira, Haiuly Viana Gonçalves de, Galdioli, Lucas, Guerrios, Simone, Gebara, Rosangela Ribeiro, Garcia, Rita de Cassia Maria   +5 more
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Evaluation of Population Management Based on Trap–Neuter–Return and Trap–Neuter–Adoption Practices in a Free-Roaming Cat Colony in the Federal District, Brazil

Animals
Overpopulation of domestic animals leads to various problems, such as the formation of feline colonies. Population management methods for these colonies have been studied previously; however, no scientific consensus has been reached. This study evaluated
Ana Nira Nunes Junqueira, Paula Diniz Galera   +1 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Transformations of traditional land use and settlement patterns of Kosarysche Ridge (Chornohora, Western Ukraine)

Bulletin of Geography. Socio-Economic Series, 2014
The traditional character of Hutsul villages and their spatial development has been changing slowly but inevitably over the course of time. Historically, single farmsteads were built separately and were mostly self-sufficient, the distance between them ...
Nowak Agnieszka, Tokarczyk Natalia
doaj   +2 more sources