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Transcript of Commission to Eliminate Child Abuse and Neglect Fatalities Hearing: February 14, 2016

open access: yes, 2016
Transcript of a public teleconference held by the Commission to Eliminate Child Abuse and Neglect Fatalities (CECANF) on February 14, 2016.This meeting includes deliberation on recommendations for the Commission's final report to the President and ...
CQ Transcriptions
core  

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

open access: yesAdvanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu   +8 more
wiley   +1 more source

Transcript of Commission to Eliminate Child Abuse and Neglect Fatalities Hearing: January 14, 2016

open access: yes, 2016
Transcript of a public teleconference held by the Commission to Eliminate Child Abuse and Neglect Fatalities (CECANF) on January 14, 2016.This meeting includes deliberation on recommendations for its final report to the President and ...
CQ Transcriptions
core  

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

open access: yesAdvanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang   +12 more
wiley   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

open access: yesAdvanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen   +10 more
wiley   +1 more source

Transcript of Commission to Eliminate Child Abuse and Neglect Fatalities Hearing: January 30, 2016

open access: yes, 2016
Transcript of a public teleconference held by the Commission to Eliminate Child Abuse and Neglect Fatalities (CECANF) on January 30, 2016. This meeting includes deliberation by the Commission on recommendations for its final report to the President and ...
CQ Transcriptions
core  

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

open access: yesAdvanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li   +13 more
wiley   +1 more source

Transcript of Commission to Eliminate Child Abuse and Neglect Fatalities Hearing: August 26, 2015

open access: yes, 2015
Transcript of a public teleconference held by the Commission to Eliminate Child Abuse and Neglect Fatalities (CECANF) on August 26, 2015. This meeting includes opening remarks by Chairman Sanders, a discussion about National Strategy Document, and plans
CQ Transcriptions
core  

An Immediate‐Response Detection System for γ‐Hydroxybutyrate to Enhance Personal Safety in Social Environments

open access: yesAdvanced Science, EarlyView.
A graphene‐based electrical biosensor enables rapid and highly sensitive detection of GHB at 100 fm in both standard solutions and artificial urine, providing reliable point‐of‐need screening for drug‐facilitated sexual assault. The platform demonstrates strong selectivity, fast response, and a wide dynamic range, supporting accurate detection in ...
Jai Eun An   +8 more
wiley   +1 more source

Transcript of Commission to Eliminate Child Abuse and Neglect Fatalities Hearing: February 15, 2016

open access: yes, 2016
Transcript of a public teleconference held by the Commission to Eliminate Child Abuse and Neglect Fatalities (CECANF) on February 15, 2016.
CQ Transcriptions
core  

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