Results 51 to 60 of about 414,058 (288)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Improving prevention of family violence during (and after) disaster: Lessons learned from the Covid-19 pandemic

Forensic Science International: Reports, 2021
As feared by many, our dedicated actions to slow the spread of COVID-19 significantly impacted reporting for most forms of family violence. This concerning decline in reports was greatest during periods of lockdown, when risk of abuse was likely at its ...
Andrew M. Campbell
doaj   +1 more source

The Admissibility of Evidence of Animal Abuse in Criminal Trials for Child and Domestic Abuse [PDF]

, 2002
Household violence is a serious problem throughout the country. When household \u27violence cases reach the court system they present unique evidentiary problems. Courts have begun to address these evidentiary problems by allowing evidence of prior abuse
Campbell, Angela
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Can childhood animal cruelty be learned?: examining age of onset and recurrency [PDF]

, 2014
Few studies have examined how animal cruelty can be a learned behavior. Using data collected from 257 male inmates at a Southern state medium-security prison, the current study seeks to replicate the Hensley, Tallichet and Dutkiewicz (2012) study.
Browne, John A.
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Classification of cases of animal abuse in Ecuador using IndetermSoft and C4.5 algorithms [PDF]

Neutrosophic Sets and Systems
This dissertation aimed to determine the classification of animal abuse within Ecuador by severity, con text, and solution through the application of IndetermSoft and the statistical-neutrosophic C4.5 algorithm to classify the uncertainty associated with
Viviana del Rocío Marfetan Marfetan, Lesly Gissela Tipanguano Chicaiza, Styven Andrés Pila Chicaiza, Estephany Monserrath Ojeda Sanchez   +3 more
doaj   +1 more source

Animal abuse

, 2021
Este artículo tiene como objetivo abordar el maltrato animal analizando el perfil criminológico del agresor en términos de género, edad y condición social. También analiza las causas probables de la conducta delictiva contra los animales. Verifica, a través del análisis e interpretación de los datos recogidos en un cuestionario aplicado a Veterinarios ...
Scheffer, Gisele Kronhardt, Ayres França, Leandro, da Silva Guedes, André Felipe   +2 more
openaire   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source