Results 51 to 60 of about 1,992,397 (280)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Animal abuse and interpersonal violence from the perspective of veterinarians from Paraíba State, Brazil

Semina: Ciências Agrárias, 2022
This study aimed to obtain information about the knowledge and attitudes of veterinarians in the state of Paraíba, Brazil, regarding the care of abused animals, the profile of possible aggressors, and their perceptions of the relationship between animal ...
Thiago da Silva Brandão, Agrício Moreira Dantas Neto, Aline de Sousa Alves, Raquel Guedes Ximenes, Karla Priscila Garrido Bezerra, Arthur Willian de Lima Brasil, Sônia Correia Assis da Nóbrega, Rosangela Maria Nunes da Silva, Almir Pereira de Souza   +8 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Public Investment in Animal Protection Work: Data from Manitoba, Canada

Animals, 2020
There is a dearth of research on animal cruelty investigations policy and work, despite its importance for protecting animals from illegal forms of cruelty.
Kendra Coulter, Brittany Campbell
doaj   +1 more source

Report on abuse at the Australian Defence Force Academy [PDF]

, 2014
This review assessed accounts of abuse at the Australian Defence Force Academy, and recommends a Royal Commission. Summary The Defence Abuse Response Taskforce (Taskforce) was established on 26 november 2012 as part of the Government’s response to the ...

core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Classification of cases of animal abuse in Ecuador using IndetermSoft and C4.5 algorithms [PDF]

Neutrosophic Sets and Systems
This dissertation aimed to determine the classification of animal abuse within Ecuador by severity, con text, and solution through the application of IndetermSoft and the statistical-neutrosophic C4.5 algorithm to classify the uncertainty associated with
Viviana del Rocío Marfetan Marfetan, Lesly Gissela Tipanguano Chicaiza, Styven Andrés Pila Chicaiza, Estephany Monserrath Ojeda Sanchez   +3 more
doaj   +1 more source

The Intertwined Well-Being of Children and Non-Human Animals: An Analysis of Animal Control Reports Involving Children

Social Sciences, 2022
The well-being of children and non-human animals (subsequently referred to as animals) is often intertwined. Communities are unlikely to be able to best protect humans from abuse and harm unless they are working to ensure the safety of animals who reside
Andrew M. Campbell
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source